A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

被引：64

作者：

Wang, Benhua ^{[1
]}

Fan, Jiangli ^{[1
]}

Wang, Xianwu ^{[2
]}

Zhu, Hao ^{[1
]}

Wang, Jingyun ^{[2
]}

Mu, Huiying ^{[1
]}

Peng, Xiaojun ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

[2] Dalian Univ Technol, Dept Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 04期

关键词：

IN-VIVO; GUIDED SURGERY; CANCER; INFLAMMATION; SURVIVAL; DESIGN; TRACER;

D O I：

10.1039/c4cc08915d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.

引用

页码：792 / 795

页数：4

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