Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection

被引：72

作者：

He, Li-Hong ^{[1
,2
,3
]}

Ren, Long-Fei ^{[1
,2
,3
]}

Li, Jun-Feng ^{[4
]}

Wu, Yong-Na ^{[3
]}

Li, Xun ^{[1
,2
,3
]}

Zhang, Lei ^{[1
,2
,3
]}

机构：

[1] Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China

[2] Lanzhou Univ, Dept Gen Surg, Hosp 1, Lanzhou, Peoples R China

[3] Key Lab Biol Therapy & Regenerat Med Transformat, Lanzhou, Peoples R China

[4] Lanzhou Univ, Dept Infect Dis, Hosp 1, Lanzhou, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

COVID-19; SARS-CoV-2; intestinal flora; gut-lung axis; immunity; SCFAs; CHAIN FATTY-ACIDS; GUT MICROBIOTA; RESPIRATORY-TRACT; DENDRITIC CELLS; INFLUENZA; DISEASE; BUTYRATE; VIRUS; ACE2; CORONAVIRUS;

D O I：

10.3389/fmicb.2020.01388

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide, seriously endangering human health. In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. It is known that a healthy intestinal flora is closely related to the maintenance of pulmonary and systemic health by regulating the host immune homeostasis. Role of the "gut-lung axis" has also been well-articulated. This review provides a novel suggestion that intestinal flora may be one of the mediators of the gastrointestinal responses and abnormal immune responses in hosts caused by SARS-CoV-2; improving the composition of intestinal flora and the proportion of its metabolites through probiotics, and personalized diet could be a potential strategy to prevent and treat COVID-19. More clinical and evidence-based medical trials may be initiated to determine the strategy.

引用

页数：9

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