Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction

被引：42

作者：

Poudel, Tej Narayan ^{[1
]}

Lee, Yong Rok ^{[1
]}

Kim, Sung Hong ^{[2
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Kyongsan 712749, South Korea

[2] Korea Basic Sci Inst, Anal Res Div, Daegu Ctr, Taegu 702701, South Korea

来源：

GREEN CHEMISTRY | 2015年 / 17卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

BIOLOGICAL EVALUATION; INHIBITORS; DESIGN; CYCLOADDITION; PYRIDONES; DERIVATIVES; CYCLIZATION; ALKYNES; IDENTIFICATION; CONSTRUCTION;

D O I：

10.1039/c5gc01526j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and highly eco-friendly synthesis of diverse and functionalized 2-pyridone derivatives in good yield via the thermal multicomponent reaction of 4-oxo-4H-chromene-3-carbaldehydes with 1,3-diketoesters and anilines or primary aliphatic amines under catalyst-and solvent-free conditions is described. This reaction proceeds via domino Knoevenagel condensation/Michael addition/ring opening/ring closure reactions.

引用

页码：4579 / 4586

页数：8

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