Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction

被引：42
|
作者：
Poudel, Tej Narayan [1 ]
Lee, Yong Rok [1 ]
Kim, Sung Hong [2 ]
机构：
[1] Yeungnam Univ, Sch Chem Engn, Kyongsan 712749, South Korea
[2] Korea Basic Sci Inst, Anal Res Div, Daegu Ctr, Taegu 702701, South Korea
来源：
GREEN CHEMISTRY | 2015年 / 17卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
BIOLOGICAL EVALUATION; INHIBITORS; DESIGN; CYCLOADDITION; PYRIDONES; DERIVATIVES; CYCLIZATION; ALKYNES; IDENTIFICATION; CONSTRUCTION;
D O I：
10.1039/c5gc01526j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and highly eco-friendly synthesis of diverse and functionalized 2-pyridone derivatives in good yield via the thermal multicomponent reaction of 4-oxo-4H-chromene-3-carbaldehydes with 1,3-diketoesters and anilines or primary aliphatic amines under catalyst-and solvent-free conditions is described. This reaction proceeds via domino Knoevenagel condensation/Michael addition/ring opening/ring closure reactions.
引用
收藏
页码：4579 / 4586
页数：8
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