Development of novel pyruvate kinase muscle isoform 2 (PKM2) activators for photoreceptor neuroprotection

被引:0
|
作者
Wubben, Thomas J. [1 ]
Rech, Jason C. [2 ]
Pawar, Mercy D. [1 ]
Weh, Eric [1 ]
Besirli, Cagri G. [1 ]
机构
[1] Univ Michigan, Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Internal Med, Ann Arbor, MI 48109 USA
关键词
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
4938
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis
    Wubben, Thomas J.
    Chaudhury, Sraboni
    Watch, Brennan T.
    Stuckey, Jeanne A.
    Weh, Eric
    Fernando, Roshini
    Goswami, Moloy
    Pawar, Mercy
    Rech, Jason C.
    Besirli, Cagri G.
    PHARMACEUTICALS, 2023, 16 (05)
  • [2] Novel PKM2 activators for photoreceptor neuroprotection: identifying potential clinical candidates
    Chaudhury, Sraboni
    Rech, Jason
    Watch, Brennan
    Weh, Eric
    Hager, Heather
    Wubben, Thomas J.
    Besirli, Cagri G.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2022, 63 (07)
  • [3] Potential cancer therapy for activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection
    Wubben, Thomas
    Pawar, Mercy D.
    Weh, Eric
    Lutrzykowska, Zuzanna
    Smith, Andrew
    Besirli, Cagri G.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [4] ZNF217 interacts with the tumorigenic isoform of pyruvate kinase PKM2
    Rahmy, S.
    Hartland, E.
    Smith, L.
    Huang, G.
    Collins, C.
    Littlepage, L. E.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [5] Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis
    Wubben, Thomas J.
    Pawar, Mercy
    Weh, Eric
    Smith, Andrew
    Sajjakulnukit, Peter
    Zhang, Li
    Dai, Lipeng
    Hager, Heather
    Pai, Manjunath P.
    Lyssiotis, Costas A.
    Besirli, Cagri G.
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [6] Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis
    Thomas J. Wubben
    Mercy Pawar
    Eric Weh
    Andrew Smith
    Peter Sajjakulnukit
    Li Zhang
    Lipeng Dai
    Heather Hager
    Manjunath P. Pai
    Costas A. Lyssiotis
    Cagri G. Besirli
    Scientific Reports, 10
  • [7] Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
    Chhipa, Abu Sufiyan
    Patel, Snehal
    LIFE SCIENCES, 2021, 280
  • [8] Role of Pyruvate Kinase 2 Muscle (PKM2) Oligomerization in Pulmonary Arterial Hypertension
    Rai, N.
    Novoyatleva, T.
    Weissmann, N.
    Ghofrani, H.
    Schermuly, R. T.
    Seeger, W.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [9] Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)
    Xu, Yong
    Liu, Xiao-Hui
    Saunders, Michael
    Pearce, Scott
    Foulks, Jason M.
    Parnell, K. Mark
    Clifford, Adrianne
    Nix, Rebecca N.
    Bullough, Jeremy
    Hendrickson, Thomas F.
    Wright, Kevin
    McCullar, Michael V.
    Kanner, Steven B.
    Ho, Koc-Kan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (02) : 515 - 519
  • [10] PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
    Israelsen, William J.
    Dayton, Talya L.
    Davidson, Shawn M.
    Fiske, Brian P.
    Hosios, Aaron M.
    Bellinger, Gary
    Li, Jie
    Yu, Yimin
    Sasaki, Mika
    Horner, James W.
    Burga, Laura N.
    Xie, Jianxin
    Jurczak, Michael J.
    DePinho, Ronald A.
    Clish, Clary B.
    Jacks, Tyler
    Kibbey, Richard G.
    Wulf, Gerburg M.
    Di Vizio, Dolores
    Mills, Gordon B.
    Cantley, Lewis C.
    Vander Heiden, Matthew G.
    CELL, 2013, 155 (02) : 397 - 409