Role of axonal transport in neurodegenerative diseases

被引：551

作者：

De Vos, Kurt J. ^{[1
]}

Grierson, Andrew J. ^{[2
]}

Ackerley, Steven ^{[1
]}

Miller, Christopher C. J. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC, Ctr Neurodegenerat Disorders, London SE5 8AF, England

[2] Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Neurol, Sheffield S10 2RX, S Yorkshire, England

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2008年 / 31卷

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

amyotrophic lateral sclerosis; motor neuron disease; Charcot-Marie-Tooth disease; Alzheimer's disease; Huntington's disease; Parkinson's disease;

D O I：

10.1146/annurev.neuro.31.061307.090711

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.

引用

页码：151 / 173

页数：23

共 143 条

[41]

Guidato S, 1996, J NEUROCHEM, V66, P1698

[42] Disruption of axonal transport by loss of huntingtin or expression of pathogenic PolyQ proteins in Drosophila [J].

Gunawardena, S ;

Her, LS ;

Brusch, RG ;

Laymon, RA ;

Niesman, IR ;

Gordesky-Gold, B ;

Sintasath, L ;

Bonini, NM ;

Goldstein, LSB .

NEURON, 2003, 40 (01) :25-40

[43] Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking [J].

Hadano, S ;

Benn, SC ;

Kakuta, S ;

Otomo, A ;

Sudo, K ;

Kunita, R ;

Suzuki-Utsunomiya, K ;

Mizumura, H ;

Shefner, JM ;

Cox, GA ;

Iwakura, Y ;

Brown, RH ;

Ikeda, JE .

HUMAN MOLECULAR GENETICS, 2006, 15 (02) :233-250

[44] Mutations in dynein link motor neuron degeneration to defects in retrograde transport [J].

Hafezparast, M ;

Klocke, R ;

Ruhrberg, C ;

Marquardt, A ;

Ahmad-Annuar, A ;

Bowen, S ;

Lalli, G ;

Witherden, AS ;

Hummerich, H ;

Nicholson, S ;

Morgan, PJ ;

Oozageer, R ;

Priestley, JV ;

Averill, S ;

King, VR ;

Ball, S ;

Peters, J ;

Toda, T ;

Yamamoto, A ;

Hiraoka, Y ;

Augustin, M ;

Korthaus, D ;

Wattler, S ;

Wabnitz, P ;

Dickneite, C ;

Lampel, S ;

Boehme, F ;

Peraus, G ;

Popp, A ;

Rudelius, M ;

Schlegel, J ;

Fuchs, H ;

de Angelis, MH ;

Schiavo, G ;

Shima, DT ;

Russ, AP ;

Stumm, G ;

Martin, JE ;

Fisher, EMC .

SCIENCE, 2003, 300 (5620) :808-812

[45] A hundred years of Alzheimer's disease research [J].

Hardy, John .

NEURON, 2006, 52 (01) :3-13

[46] Genetics of Parkinson's disease and parkinsonism [J].

Hardy, John ;

Cai, Huaiban ;

Cookson, Mark R. ;

Gwinn-Hardy, Katrina ;

Singleton, Andrew .

ANNALS OF NEUROLOGY, 2006, 60 (04) :389-398

[47] Molecular motors and mechanisms of directional transport in neurons [J].

Hirokawa, N ;

Takemura, R .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (03) :201-214

[48]

Hiruma H, 2003, J NEUROSCI, V23, P8967

[49] Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy [J].

Irobi, J ;

Van Impe, K ;

Seeman, P ;

Jordanova, A ;

Dierick, I ;

Verpoorten, N ;

Michalik, A ;

De Vriendt, E ;

Jacobs, A ;

Van Gerwen, V ;

Vennekens, K ;

Mazanec, R ;

Tournev, I ;

Hilton-Jones, D ;

Talbot, K ;

Kremensky, N ;

Van Den Bosch, L ;

Robberecht, W ;

Vandekerckhove, J ;

Van Broeckhoven, C ;

Gettemans, J ;

De Jonghe, P ;

Timmerman, V .

NATURE GENETICS, 2004, 36 (06) :597-601

[50] Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform [J].

Ishihara, T ;

Hong, M ;

Zhang, B ;

Nakagawa, Y ;

Lee, MK ;

Trojanowski, JQ ;

Lee, VMY .

NEURON, 1999, 24 (03) :751-762

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