Role of axonal transport in neurodegenerative diseases

被引：552

作者：

De Vos, Kurt J. ^{[1
]}

Grierson, Andrew J. ^{[2
]}

Ackerley, Steven ^{[1
]}

Miller, Christopher C. J. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC, Ctr Neurodegenerat Disorders, London SE5 8AF, England

[2] Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Neurol, Sheffield S10 2RX, S Yorkshire, England

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2008年 / 31卷

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

amyotrophic lateral sclerosis; motor neuron disease; Charcot-Marie-Tooth disease; Alzheimer's disease; Huntington's disease; Parkinson's disease;

D O I：

10.1146/annurev.neuro.31.061307.090711

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.

引用

页码：151 / 173

页数：23

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