LIGNAN DERIVATIVES FROM THE LEAVES NICOTIANA TABACUM AND THEIR ACTIVITIES

被引：64

作者：

Gao, Xuemei ^{[1
,2
]}

Li, Xuesen ^{[1
,2
,3
]}

Yang, Xinzhou ^{[1
,2
]}

Mu, Huaixue ^{[1
,2
]}

Chen, Yongkuan ^{[3
]}

Yang, Guangyu ^{[3
]}

Hu, Qiufen ^{[1
,2
]}

机构：

[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China

[2] Minist Educ, Kunming 650031, Peoples R China

[3] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China

来源：

HETEROCYCLES | 2012年 / 85卷 / 01期

关键词：

Nicotiana tabacum; Norlignan; Anti-HIV-1; Activity; Anti-Tobacco Mosaic Virus Activity; TOBACCO; IDENTIFICATION; CHEMISTRY;

D O I：

10.3987/COM-11-12349

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new lignan derivatives, nicotnorlignan A and nicotlactone A (1, 2), together with two known lignan derivatives (3, 4) were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-4 were tested for their anti-HIV-1 activity and anti-tobacco mosaic virus activities. The results showed compound 2 has high anti-tobacco mosaic virus activities, and all other compounds have modest anti-HIV-1 activity and anti-tobacco mosaic virus activities.

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收藏

页码：147 / 153

页数：7

相关论文

共 25 条

[1]

Angkhana I., 2008, J ETHNOPHARMACOL, V116, P134

[2] N'-ETHYLNORNICOTINE FROM BURLEY TOBACCO [J].

BRAUMANN, T ;

NICOLAUS, G ;

HAHN, W ;

ELMENHORST, H .

PHYTOCHEMISTRY, 1990, 29 (11) :3693-3694

[3] The use of magical plants by curanderos in the Ecuador highlands [J].

Cavender, Anthony P. ;

Alban, Manuel .

JOURNAL OF ETHNOBIOLOGY AND ETHNOMEDICINE, 2009, 5

[4] Recent advancements for the evaluation of anti-viral activities of natural products [J].

Chattopadhyay, Debprasad ;

Chawla-Sarkar, Mamta ;

Chatterjee, Tapan ;

Dey, Rakhi Sharma ;

Bag, Paromita ;

Chakraborti, Sekhar ;

Khan, Mahmud Tareq Hassan .

NEW BIOTECHNOLOGY, 2009, 25 (05) :347-368

[5] Chemical Constituents of the Bark of Machilus wangchiana and Their Biological Activities [J].

Cheng, Wei ;

Zhu, Chenggen ;

Xu, Wendong ;

Fan, Xiaona ;

Yang, Yongchun ;

Li, Yan ;

Chen, Xiaoguang ;

Wang, Wenjie ;

Shi, Jiangong .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (12) :2145-2152

[6]

Darke P L, 1994, Adv Pharmacol, V25, P399, DOI 10.1016/S1054-3589(08)60438-X

[7] THE CHEMISTRY OF BRAZILIAN LAURACEAE .91. BENZODIOXANE AND BETA-ARYLOXY-ARYLPROPANE TYPE NEOLIGNANS FROM LICARIA-CHRYSOPHYLLA [J].

DASILVA, MS ;

BARBOSAFILHO, JM ;

YOSHIDA, M ;

GOTTLIEB, OR .

PHYTOCHEMISTRY, 1989, 28 (12) :3477-3482

[8] Terpenoids and Norlignans from Metasequoia glyptostroboides [J].

Dong, Liao-Bin ;

He, Juan ;

Wang, Yuan-Yuan ;

Wu, Xing-De ;

Deng, Xu ;

Pan, Zheng-Hong ;

Xu, Gang ;

Peng, Li-Yan ;

Zhao, Yu ;

Li, Yan ;

Gong, Xun ;

Zhao, Qin-Shi .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (02) :234-239

[9] In vitro hydroxylation of a norlignan: From agatharesinol to sequirin C and metasequirin C with a microsomal preparation from Cryptomeria japonica [J].

Imai, Takanori ;

Asai, Kensuke ;

Takino, Mana ;

Fukushima, Kazuhiko .

PHYTOCHEMISTRY LETTERS, 2009, 2 (04) :196-200

[10] Preparation of high surface area activated carbons from tobacco stems with K2CO3 activation using microwave radiation [J].

Li, Wei ;

Zhang, Li-bo ;

Peng, Jin-hui ;

Li, Ning ;

Zhu, Xue-yun .

INDUSTRIAL CROPS AND PRODUCTS, 2008, 27 (03) :341-347