LIGNAN DERIVATIVES FROM THE LEAVES NICOTIANA TABACUM AND THEIR ACTIVITIES

被引：65
作者：
Gao, Xuemei [1 ,2 ]
Li, Xuesen [1 ,2 ,3 ]
Yang, Xinzhou [1 ,2 ]
Mu, Huaixue [1 ,2 ]
Chen, Yongkuan [3 ]
Yang, Guangyu [3 ]
Hu, Qiufen [1 ,2 ]
机构：
[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
[2] Minist Educ, Kunming 650031, Peoples R China
[3] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China
来源：
HETEROCYCLES | 2012年 / 85卷 / 01期
关键词：
Nicotiana tabacum; Norlignan; Anti-HIV-1; Activity; Anti-Tobacco Mosaic Virus Activity; TOBACCO; IDENTIFICATION; CHEMISTRY;
D O I：
10.3987/COM-11-12349
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new lignan derivatives, nicotnorlignan A and nicotlactone A (1, 2), together with two known lignan derivatives (3, 4) were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-4 were tested for their anti-HIV-1 activity and anti-tobacco mosaic virus activities. The results showed compound 2 has high anti-tobacco mosaic virus activities, and all other compounds have modest anti-HIV-1 activity and anti-tobacco mosaic virus activities.
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页码：147 / 153
页数：7
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