On the road to cancer: Aneuploidy and the mitotic checkpoint

被引：925

作者：

Kops, GJPL ^{[1
]}

Weaver, BAA

Cleveland, DW

机构：

[1] Univ Med Ctr, Dept Med Oncol, Expt Oncol Lab, NL-3584 CG Utrecht, Netherlands

[2] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrc1714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.

引用

页码：773 / 785

页数：13

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