Phomopsinones A-D: Four New Pyrenocines from Endophytic Fungus Phomopsis sp.

被引：43

作者：

Hussain, Hidayat ^{[1
]}

Krohn, Karsten ^{[1
]}

Ahmed, Ishtiaq ^{[1
]}

Draeger, Siegfried ^{[2
]}

Schulz, Barbara ^{[2
]}

Di Pietro, Sebastiano ^{[3
]}

Pescitelli, Gennaro ^{[3
]}

机构：

[1] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany

[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Mikrobiol, D-31806 Braunschweig, Germany

[3] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 09期

关键词：

Natural products; Structure elucidation; Circular dichroism; Biological activity; NATURAL-PRODUCTS; ISOCOUMARINS; METABOLITES; DIVERSITY;

D O I：

10.1002/ejoc.201101788

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structural elucidation of the compounds isolated from the endophytic Phomopsis sp. revealed phomopsinones AD (14), four new a-pyrone derivatives. Three known compounds were also isolated, namely two phomosines, phomosine A (5) and phomosine C (6), and ergosterol (7). The structures of these compounds were determined by spectroscopic analysis (1H, 13C, 1H1H COSY, HMQC, HMBC, and ROESY NMR, and mass spectrometry), supported by molecular modeling. The absolute configurations of the new compounds 14 were determined by circular dichroism spectroscopy and TDDFT calculations. Preliminary studies indicated that compounds 1 and 4 show strong and good antifungal activity, respectively. Similarly, compounds 2 and 3 showed good antifungal and moderate antibacterial activities as well as antialgal activities.

引用

页码：1783 / 1789

页数：7

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