Contrast enhanced gray-scale sonography in assessment of joint vascularity in rheumatoid arthritis: results from the IACUS study group

被引:108
作者
Klauser, A [1 ]
Demharter, J
De Marchi, A
Sureda, D
Barile, A
Masciocchi, C
Faletti, C
Schirmer, M
Kleffel, T
Bohndorf, K
机构
[1] Med Univ Innsbruck, Dept Radiol & Internal Med 2, A-6020 Innsbruck, Austria
[2] Zent Klinikum, Clin Diagnost Radiol & Neuroradiol, D-86156 Augsburg, Germany
[3] Adelaide CTO Hosp, Dept Radiol, I-10128 Turin, Italy
[4] Hosp Valle De Hebron, Dept Radiol, Barcelona 08035, Spain
[5] Univ Aquila, Dept Radiol, I-67101 Laquila, Italy
关键词
contrast enhanced gray-scale ultrasound; power Doppler ultrasound; rheumatoid arthritis; inflammatory activity; synovitis; joint;
D O I
10.1007/s00330-005-2884-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The purpose of this study way to assess the value of contrast enhanced gray-scale ultrasound (CEUS) in detection of vascularity in joints of patients with rheumatoid arthritis (RA) in a multicenter study of the International Arthritis Contrast Ultrasound (IACUS) study group. We assessed 113 joints in 113 patients (44 men, 69 women; mean age 51 +/- 14 years) with clinical diagnosis of RA. Gray-scale ultrasound (US), power Doppler US (PDUS) and CEUS, using a low mechanical index US technique, was performed. CEUS was done by bolus administration of the contrast agent SonoVue (Bracco, Milan, Italy) with a dosage of 4.8-ml SonoVue flushed with 10 ml saline. Detection of joint vascularity was performed for differentiation of active synovitis from inactive intra-articular thickening (synovitis/effusion). With the use of US and PDUS, active synovitis could be differentiated from inactive intra-articular thickening in 68/113 joints (60.1%), whereas CEUS enabled differentiation in 110/113 (97.3%) joints (p < 0.0001). Thickness measurement of active synovitis was significantly improved after contrast administration (p=0.008). In conclusion, CEUS improves the differentiation of active synovitis from inactive intra-articular thickening. Since CEUS has shown an ability to improve assessment of vascularized synovial proliferation in RA affected joints, this technique may have further potential in monitoring therapy.
引用
收藏
页码:2404 / 2410
页数:7
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