Spirocyclic oxetanes:: Synthesis and properties

被引：167

作者：

Wuitschik, Georg ^{[2
]}

Rogers-Evans, Mark ^{[1
]}

Buckl, Andreas

Bernasconi, Maurizio

Maerki, Moritz

Godel, Thierry ^{[1
]}

Fischer, Holger ^{[1
]}

Wagner, Bjoern ^{[1
]}

Parrilla, Isabelle ^{[1
]}

Schuler, Franz ^{[1
]}

Schneider, Josef ^{[1
]}

Alker, Andre ^{[1
]}

Schweizer, W. Bernd

Mueller, Klaus ^{[1
]}

Carreira, Erick M. ^{[2
]}

机构：

[1] F Hoffmann La Roche & Cie AG, Div Pharmaceut, CH-4070 Basel, Switzerland

[2] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 24期

关键词：

carbonyl compounds; heterocycles; morpholine; oxetanes; spiro compounds;

D O I：

10.1002/anie.200800450

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Presented) Wormholes through chemical space: Spirocyclic oxetanes are described as analogues of morpholine and also as topological siblings of their carbonyl counterparts. They are particularly promising in terms of both their physicochemical properties and the ease with which they can be grafted onto molecular structures. The data collected highlight oxetanes as both the hydrophilic sister of a gem-dimethyl unit and the carbonyl group's lipophilic brother. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4512 / 4515

页数：4

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