A biopotential optrode array: operation principles and simulations

被引：23

作者：

Al Abed, Amr ^{[1
]}

Srinivas, Hrishikesh ^{[1
,2
]}

Firth, Josiah ^{[2
]}

Ladouceur, Francois ^{[2
]}

Lovell, Nigel H. ^{[1
]}

Silvestri, Leonardo ^{[1
,2
]}

机构：

[1] UNSW, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia

[2] UNSW, Sch Elect Engn & Telecommun, Sydney, NSW 2052, Australia

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

澳大利亚研究理事会;

关键词：

ELECTROCHEMICAL TRANSISTOR ARRAYS; MULTIELECTRODE ARRAY; MICROELECTRODE ARRAYS; MODEL; INTERFACE; NEUROSCIENCE; TECHNOLOGY; RECORDINGS; PLATFORM; TOOL;

D O I：

10.1038/s41598-018-20182-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose an optical electrode 'optrode' sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode's light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electrooptical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue.

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