Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA

被引：9

作者：

Park, Myunji ^{[1
]}

Bruice, Thomas C. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 12期

关键词：

DNG (deoxyribonucleic guanidine); melting temperature; antisense agents;

D O I：

10.1016/j.bmcl.2008.05.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The melting properties of hexameric oligonucleotide AgTgAgTgAgT, in which the phosphodiester linkages of the DNA have been replaced by guanidium linkages, have been evaluated. Using the juvenile esterase gene as a target, the binding of a 20-mer DNG/DNA chimera that includes AgTgAgTgAgT is more than 10(5.7) stronger than the binding of 20-mer composed solely of DNA. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3488 / 3491

页数：4

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