Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp (Tree1-7)

被引：40

作者：

Wen, Lu ^{[2
,3
,4
]}

Lin, Yong-Cheng ^{[2
,3
]}

She, Zhi-Gang ^{[2
,3
]}

Du, Dun-Shuai ^{[2
,3
]}

Chan, Wing-Lai ^{[1
]}

Zheng, Zhong-Hui ^{[5
]}

机构：

[1] Hong Kong Polytech Univ, Dept Biol & Chem, Hong Kong, Peoples R China

[2] Sun Yat Sen Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China

[3] Sun Yat Sen Zhongshan Univ, Sch Pharmaceut Sci, Guangzhou 510275, Peoples R China

[4] Guangdong Pharmaceut Univ, Coll Pharm, Guangzhou 510006, Peoples R China

[5] Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Paecilomyces sp; Paeciloxanthone; marine mangrove fungus; HepG2; toxicity;

D O I：

10.1080/10286020701273783

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The metatrophic fungus Paecilomyces sp. (Tree1-7) was isolated from an estuarine mangrove from the Taiwan Strait. The methanol extract of the fungal mycelium exhibited cytotoxicity against hepG2. Paeciloxanthone (1), a new xanthone, and the known compounds emodin (2) and chrysophanol (3), were isolated from the extract. Their structures were elucidated by spectroscopic experiments. Paeciloxanthone (1) exhibited in vitro cytotoxicity against hepG2 (IC50 = 1.08 mu g/mL), acetylcholi-neesterase (AChE) inhibitory (IC50 2.25 mu g/mL) and antimicrobial activities.

引用

页码：133 / 137

页数：5

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