Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective

被引：56

作者：

Alvarez-Viejo, Maria ^{[1
,2
]}

机构：

[1] Hosp Univ Cent Asturias, Unidad Terapia Celular & Med Regenerat, Serv Hematol & Hemoterapia, Oviedo 33011, Spain

[2] Inst Invest Sanitaria Principado Asturias, Plataforma Terapias Avanzadas, Oviedo 33011, Spain

来源：

WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 02期

关键词：

Mesenchymal stem cells; Exosomes; Cellular therapy; EXTRACELLULAR VESICLES; PARACRINE ACTION; MICROVESICLES;

D O I：

10.4252/wjsc.v12.i2.100

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Since the introduction of cell therapy as a strategy for the treatment of many diseases, mesenchymal stem cells have emerged as ideal candidates, yet the underlying mechanisms of their beneficial effects are only partially understood. At the start of the 21st century, a paracrine effect was proposed as a mechanism of tissue repair by these cells. In addition, a role was suggested for a heterogeneous population of extracellular vesicles in cell-to-cell communication. Some of these vesicles including exosomes have been isolated from most fluids and cells, as well as from supernatants of in vitro cell cultures. Recent research in the field of regenerative medicine suggests that exosomes derived from mesenchymal stem cells could be a powerful new therapeutic tool. This review examines the therapeutic potential of these exosomes obtained from the sources most used in cell therapy: bone marrow, adipose tissue, and umbilical cord.

引用

页码：100 / 109

页数：10

共 50 条

[41] Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application [J].

Yamashita, Takuma ;

Takahashi, Yuki ;

Takakura, Yoshinobu .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2018, 41 (06) :835-842

[42] Biological properties of extracellular vesicles and their physiological functions [J].

Yanez-Mo, Maria ;

Siljander, Pia R. -M. ;

Andreu, Zoraida ;

Zavec, Apolonija Bedina ;

Borras, Francesc E. ;

Buzas, Edit I. ;

Buzas, Krisztina ;

Casal, Enriqueta ;

Cappello, Francesco ;

Carvalho, Joana ;

Colas, Eva ;

Cordeiro-da Silva, Anabela ;

Fais, Stefano ;

Falcon-Perez, Juan M. ;

Ghobrial, Irene M. ;

Giebel, Bernd ;

Gimona, Mario ;

Graner, Michael ;

Gursel, Ihsan ;

Gursel, Mayda ;

Heegaard, Niels H. H. ;

Hendrix, An ;

Kierulf, Peter ;

Kokubun, Katsutoshi ;

Kosanovic, Maja ;

Kralj-Iglic, Veronika ;

Kraemer-Albers, Eva-Maria ;

Laitinen, Saara ;

Lasser, Cecilia ;

Lener, Thomas ;

Ligeti, Erzsebet ;

Line, Aija ;

Lipps, Georg ;

Llorente, Alicia ;

Lotvall, Jan ;

Mancek-Keber, Mateja ;

Marcilla, Antonio ;

Mittelbrunn, Maria ;

Nazarenko, Irina ;

Nolte-t' Hoen, Esther N. M. ;

Nyman, Tuula A. ;

O'Driscoll, Lorraine ;

Olivan, Mireia ;

Oliveira, Carla ;

Pallinger, Eva ;

del Portillo, Hernando A. ;

Reventos, Jaume ;

Rigau, Marina ;

Rohde, Eva ;

Sammar, Marei .

JOURNAL OF EXTRACELLULAR VESICLES, 2015, 4 :1-60

[43] Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway [J].

Zhang, Bin ;

Yeo, Ronne Wee Yeh ;

Lai, Ruenn Chai ;

Sim, Eugene Wei Kian ;

Chin, Keh Chuang ;

Lim, Sai Kiang .

CYTOTHERAPY, 2018, 20 (05) :687-696

[44] Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/β-Catenin Pathway [J].

Zhang, Bin ;

Wu, Xiaodan ;

Zhang, Xu ;

Sun, Yaoxiang ;

Yan, Yongmin ;

Shi, Hui ;

Zhu, Yanhua ;

Wu, Lijun ;

Pan, Zhaoji ;

Zhu, Wei ;

Qian, Hui ;

Xu, Wenrong .

STEM CELLS TRANSLATIONAL MEDICINE, 2015, 4 (05) :513-522

[45] Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway [J].

Zhang, Wei ;

Bai, Xiaozhi ;

Zhao, Bin ;

Li, Yan ;

Zhang, Yijie ;

Li, Zhenzhen ;

Wang, Xujie ;

Luo, Liang ;

Han, Fu ;

Zhang, Julei ;

Han, Shichao ;

Cai, Weixia ;

Su, Linlin ;

Tao, Ke ;

Shi, Jihong ;

Hu, Dahai .

EXPERIMENTAL CELL RESEARCH, 2018, 370 (02) :333-342

[46] Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes [J].

Zhang, Xiaomin ;

Liu, Juping ;

Yu, Bo ;

Ma, Feifei ;

Ren, Xinjun ;

Li, Xiaorong .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2018, 256 (11) :2041-2052

[47] A unified explicit analytical expression for considering anomalous eddy-current losses of ME laminate [J].

Zhang, Yongfei ;

Zhang, Gang ;

Zheng, Xiaobo ;

He, Shuanhai .

MATERIALS RESEARCH EXPRESS, 2019, 6 (12)

[48]

Zhou J, 2019, EUR REV MED PHARMACO, V23, P4954, DOI 10.26355/eurrev_201906_18086

[49] Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes [J].

Zhu, Yu ;

Jia, Yachao ;

Wang, Yanmao ;

Xu, Jia ;

Chai, Yimin .

STEM CELLS TRANSLATIONAL MEDICINE, 2019, 8 (06) :593-605

[50] Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis [J].

Zhu, Yu ;

Wang, Yuchen ;

Zhao, Bizeng ;

Niu, Xin ;

Hu, Bin ;

Li, Qing ;

Zhang, Juntao ;

Ding, Jian ;

Chen, Yunfeng ;

Wang, Yang .

STEM CELL RESEARCH & THERAPY, 2017, 8

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