Emerging mechanisms of neutrophil recruitment across endothelium

被引:212
作者
Williams, Marcie R.
Azcutia, Veronica
Newton, Gail
Alcaide, Pilar
Luscinskas, Francis W. [1 ]
机构
[1] Brigham & Womens Hosp, Dept Pathol, Ctr Excellence Vasc Biol, Boston, MA 02115 USA
关键词
LEUKOCYTE RECRUITMENT; VE-CADHERIN; POLYMORPHONUCLEAR LEUKOCYTES; VASCULAR-PERMEABILITY; PTEN; ADHESION; TRANSMIGRATION; RECOGNITION; RECEPTORS; MIGRATION;
D O I
10.1016/j.it.2011.06.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neutrophils are the all-terrain vehicle of the innate immune system because of their ability to gain entry into tissues and organs, and thus, play an essential role in host defense. Exactly how this marvel of nature works is still incompletely understood. In the past 2-3 years, new players and processes have been identified in the endothelial-leukocyte adhesion cascade. Novel signaling pathways have been discovered in both the endothelium and the neutrophils that regulate various steps in the recruitment process. This review focuses on these emerging pathways and the mechanisms that regulate neutrophil recruitment across endothelium.
引用
收藏
页码:461 / 469
页数:9
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