miRNAs in Lung Development and Diseases

被引：38

作者：

Boateng, Eistine ^{[1
]}

Krauss-Etschmann, Susanne ^{[1
,2
]}

机构：

[1] German Ctr Lung Res DZL, Leibniz Lung Ctr, Early Life Origins Chron Lung Dis, Res Ctr Borstel, D-23845 Borstel, Germany

[2] Christian Albrechts Univ Kiel, Inst Expt Med, D-24118 Kiel, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 08期

关键词：

lung development; lung diseases; miRNA; human; mouse; PULMONARY ARTERIAL-HYPERTENSION; BRONCHIAL EPITHELIAL-CELLS; NF-KAPPA-B; STEM-CELLS; FIBROSIS; DIFFERENTIATION; EXPRESSION; BETA; PROLIFERATION; MICRORNAS;

D O I：

10.3390/ijms21082765

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of the lung involves a diverse group of molecules that regulate cellular processes, organ formation, and maturation. The various stages of lung development are marked by accumulation of small RNAs that promote or repress underlying mechanisms, depending on the physiological environment in utero and postnatally. To some extent, the pathogenesis of various lung diseases is regulated by small RNAs. In this review, we discussed miRNAs regulation of lung development and diseases, that is, COPD, asthma, pulmonary fibrosis, and pulmonary arterial hypertension, and also highlighted possible connotations for human lung health.

引用

页数：16

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