Genetic and neuroendocrine regulation of the postpartum brain

被引：27

作者：

Gammie, Stephen C. ^{[1
,2
]}

Driessen, Terri M. ^{[1
]}

Zhao, Changjiu ^{[1
]}

Saul, Michael C. ^{[1
]}

Eisinger, Brian E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Zool, Madison, WI 53706 USA

[2] Univ Wisconsin, Neurosci Training Program, Madison, WI 53706 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2016年 / 42卷

基金：

美国国家卫生研究院;

关键词：

Maternal; Postpartum; Depression; Addiction; Reward; Social behavior; Mental health; MicroRNA; Oxytocin; Prolactin; DEPRESSION-LIKE BEHAVIOR; MEDIAL PREOPTIC AREA; REV-ERB-ALPHA; MATERNAL-BEHAVIOR; HIPPOCAMPAL NEUROGENESIS; LATERAL SEPTUM; EXPRESSION PROFILES; ALTERED EXPRESSION; PARENTAL BEHAVIOR; PLACE PREFERENCE;

D O I：

10.1016/j.yfrne.2016.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Changes in expression of hundreds of genes occur during the production and function of the maternal brain that support a wide range of processes. In this review, we synthesize findings from four microarray studies of different maternal brain regions and identify a core group of 700 maternal genes that show significant expression changes across multiple regions. With those maternal genes, we provide new insights into reward-related pathways (maternal bonding), postpartum depression, social behaviors, mental health disorders, and nervous system plasticity/developmental events. We also integrate the new genes into well-studied maternal signaling pathways, including those for prolactin, oxytocin/vasopressin, endogenous opioids, and steroid receptors (estradiol, progesterone, cortisol). A newer transcriptional regulation model for the maternal brain is provided that incorporates recent work on maternal microRNAs. We also compare the top 700 genes with other maternal gene expression studies. Together, we highlight new genes and new directions for studies on the postpartum brain. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：1 / 17

页数：17

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