Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

被引：53
作者：
Naz, M. [1 ]
Nasiri, N. [2 ,4 ]
Ikram, M. [3 ]
Nafees, M. [3 ]
Qureshi, M. Z. [1 ]
Ali, S. [3 ]
Tricoli, A. [2 ]
机构：
[1] Univ Lahore, Govt Coll, Dept Chem, Biochem Lab, Lahore 54000, Pakistan
[2] Australian Natl Univ, Res Sch Engn, Nanotechnol Res Lab, Canberra, ACT 2601, Australia
[3] Univ Lahore, Govt Coll, Dept Phys, Solar Cell Applicat Res Lab, Lahore 54000, Pakistan
[4] Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices, Sydney, NSW 2007, Australia
来源：
APPLIED NANOSCIENCE | 2017年 / 7卷 / 08期
关键词：
Drug loading; Seed extract; Cytotoxicity; Anthelmintic activity; Ag-NPs; SILVER NANOPARTICLES; REDUCTION PROCESS; FACILE SYNTHESIS; GREEN SYNTHESIS; ANTIBACTERIAL; GOLD; EXTRACT; STABILIZATION; DELIVERY; CELLS;
D O I：
10.1007/s13204-017-0615-6
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet-visible (UV-Vis) spectrophotometry. Anticancer activity of Ag-NPs (5-20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.
引用
收藏
页码：793 / 802
页数：10
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