Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

被引：49

作者：

Chen, Ran ^{[1
]}

Choudhary, Poonam ^{[1
]}

Schurr, Ryan N. ^{[1
]}

Bhattacharya, Priyanka ^{[1
]}

Brown, Jared M. ^{[2
]}

Ke, Pu Chun ^{[1
]}

机构：

[1] Clemson Univ, Lab Single Mol Biophys & Polymer Phys, COMSET, Clemson, SC 29634 USA

[2] E Carolina Univ, Dept Pharmacol & Toxicol, Greenville, NC 27834 USA

来源：

APPLIED PHYSICS LETTERS | 2012年 / 100卷 / 01期

基金：

美国国家科学基金会;

关键词：

COMPUTER-SIMULATION; GOLD NANOPARTICLES; SURFACE; TRANSLOCATION; MEMBRANES; CYTOTOXICITY; INTERFACE; BILAYER;

D O I：

10.1063/1.3672035

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein "corona" has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology. (C) 2012 American Institute of Physics. [doi: 10.1063/1.3672035]

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