Hyrtioerectines A-C, cytotoxic alkaloids from the Red Sea sponge Hyrtios erectus

被引：59
作者：
Youssef, DTA [1 ]
机构：
[1] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 09期
关键词：
D O I：
10.1021/np050142c
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A Red Sea specimen of the marine sponge Hyrtios erectus was found to contain three new alkaloids, hyrtioerectines A-C (1-3). Hyrtioerectine A (1) possesses the carbon bond-linked moieties 6-hydroxy beta-carboline and 6-hydroxyindole. The structure elucidation of 1-3 was based on intensive study of their spectral data including 1D (H-1 and C-13) and 2D (H-1-H-1 COSY, HOHAHA, NOESY, ROESY, HMQC, and HMBC) NMR, together with high-resolution mass spectra. Hyrtioerectines A-C were moderately cytotoxic.
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页码：1416 / 1419
页数：4
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