Attenuation of 1-(m-Chlorophenyl)-Biguanide Induced Hippocampus-Dependent Memory Impairment by a Standardised Extract of Bacopa monniera (BESEB CDRI-08)

被引：22

作者：

Rajan, Koilmani Emmanuvel ^{[1
]}

Singh, Hemant K. ^{[2
]}

Parkavi, Arunagiri ^{[1
]}

Charles, Prisila Dulcy ^{[1
]}

机构：

[1] Bharathidasan Univ, Dept Anim Sci, Sch Life Sci, Tiruchirappalli 620024, Tamil Nadu, India

[2] Cent Drug Res Inst, Div Pharmacol, Labs CNS Disorder Learning & Memory, Lucknow 22600, Uttar Pradesh, India

来源：

NEUROCHEMICAL RESEARCH | 2011年 / 36卷 / 11期

关键词：

Learning and memory; Bacopa monniera; BESEB CDRI-08; Hippocampus; 5-HT receptors; mCPBG; ACETYLCHOLINE-RELEASE; 5-HT3; RECEPTORS; P-CHLOROAMPHETAMINE; PASSIVE-AVOIDANCE; GABAERGIC NEURONS; RAT HIPPOCAMPUS; GENE-EXPRESSION; INDUCED AMNESIA; BRAHMI EXTRACT; EPILEPTIC RATS;

D O I：

10.1007/s11064-011-0538-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacopa monniera is a well-known medhya-rasayana (memory enhancing and rejuvenating) plant in Indian traditional medical system of Ayurveda. The effect of a standardized extract of Bacopa monniera (BESEB CDRI-08) on serotonergic receptors and its influence on other neurotransmitters during hippocampal-dependent learning was evaluated in the present study. Wistar rat pups received a single dose of BESEB CDRI-08 during postnatal days 15-29 showed higher latency during hippocampal-dependent learning accompanied with enhanced 5HT(3A) receptor expression, serotonin and acetylcholine levels in hippocampus. Furthermore, 5HT(3A) receptor agonist 1-(m-chlorophenyl)-biguanide (mCPBG) impaired learning in the passive avoidance task followed by reduction of 5HT(3A) receptor expression, 5HT and ACh levels. Administration of BESEB CDRI-08 along with mCPBG attenuated mCPBG induced behavioral, molecular and neurochemical alterations. Our results suggest that BESEB CDRI-08 possibly acts on serotonergic system, which in turn influences the cholinergic system through 5-HT3 receptor to improve the hippocampal-dependent task.

引用

页码：2136 / 2144

页数：9

共 66 条

[51] Involvement of GABA systems in acetylcholine release induced by 5-HT3 receptor blockade in slices from rat entorhinal cortex [J].

Ramirez, MJ ;

Cenarruzabeitia, E ;

Lasheras, B ;

DelRio, J .

BRAIN RESEARCH, 1996, 712 (02) :274-280

[52] Bacopa monniera, a reputed nootropic plant:: an overview [J].

Russo, A ;

Borrelli, F .

PHYTOMEDICINE, 2005, 12 (04) :305-317

[53] Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice [J].

Saraf, Manish Kumar ;

Prabhakar, Sudesh ;

Khanduja, Krishan Lal ;

Anand, Akshay .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011 :1-10

[54] Scopolamine Induced Amnesia is Reversed by Bacopa monniera Through Participation of Kinase-CREB Pathway [J].

Saraf, Manish Kumar ;

Anand, Akshay ;

Prabhakar, Sudesh .

NEUROCHEMICAL RESEARCH, 2010, 35 (02) :279-287

[55]

Siddiqui Muhammad F., 1999, Drugs of the Future, V24, P417, DOI 10.1358/dof.1999.024.04.668318

[56]

Singh H. K., 1997, Indian Journal of Pharmacology, V29, pS359

[57] EFFECT OF BACOPA-MONNIERA LINN (BRAHMI) EXTRACT ON AVOIDANCE RESPONSES IN RAT [J].

SINGH, HK ;

DHAWAN, BN .

JOURNAL OF ETHNOPHARMACOLOGY, 1982, 5 (02) :205-214

[58]

Singh HK., 1988, Phytother Res, V2, P70, DOI [DOI 10.1002/PTR.2650020205, 10.1002/ptr.2650020205]

[59] Serotonin and acetylcholine release response in the rat hippocampus during a spatial memory task [J].

Stancampiano, R ;

Cocco, S ;

Cugusi, C ;

Sarais, L ;

Fadda, F .

NEUROSCIENCE, 1999, 89 (04) :1135-1143

[60] Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats [J].

StubleyWeatherly, L ;

Harding, JW ;

Wright, JW .

BRAIN RESEARCH, 1996, 716 (1-2) :29-38

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