Attenuation of 1-(m-Chlorophenyl)-Biguanide Induced Hippocampus-Dependent Memory Impairment by a Standardised Extract of Bacopa monniera (BESEB CDRI-08)

被引：22

作者：

Rajan, Koilmani Emmanuvel ^{[1
]}

Singh, Hemant K. ^{[2
]}

Parkavi, Arunagiri ^{[1
]}

Charles, Prisila Dulcy ^{[1
]}

机构：

[1] Bharathidasan Univ, Dept Anim Sci, Sch Life Sci, Tiruchirappalli 620024, Tamil Nadu, India

[2] Cent Drug Res Inst, Div Pharmacol, Labs CNS Disorder Learning & Memory, Lucknow 22600, Uttar Pradesh, India

来源：

NEUROCHEMICAL RESEARCH | 2011年 / 36卷 / 11期

关键词：

Learning and memory; Bacopa monniera; BESEB CDRI-08; Hippocampus; 5-HT receptors; mCPBG; ACETYLCHOLINE-RELEASE; 5-HT3; RECEPTORS; P-CHLOROAMPHETAMINE; PASSIVE-AVOIDANCE; GABAERGIC NEURONS; RAT HIPPOCAMPUS; GENE-EXPRESSION; INDUCED AMNESIA; BRAHMI EXTRACT; EPILEPTIC RATS;

D O I：

10.1007/s11064-011-0538-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacopa monniera is a well-known medhya-rasayana (memory enhancing and rejuvenating) plant in Indian traditional medical system of Ayurveda. The effect of a standardized extract of Bacopa monniera (BESEB CDRI-08) on serotonergic receptors and its influence on other neurotransmitters during hippocampal-dependent learning was evaluated in the present study. Wistar rat pups received a single dose of BESEB CDRI-08 during postnatal days 15-29 showed higher latency during hippocampal-dependent learning accompanied with enhanced 5HT(3A) receptor expression, serotonin and acetylcholine levels in hippocampus. Furthermore, 5HT(3A) receptor agonist 1-(m-chlorophenyl)-biguanide (mCPBG) impaired learning in the passive avoidance task followed by reduction of 5HT(3A) receptor expression, 5HT and ACh levels. Administration of BESEB CDRI-08 along with mCPBG attenuated mCPBG induced behavioral, molecular and neurochemical alterations. Our results suggest that BESEB CDRI-08 possibly acts on serotonergic system, which in turn influences the cholinergic system through 5-HT3 receptor to improve the hippocampal-dependent task.

引用

页码：2136 / 2144

页数：9

共 66 条

[1] Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission [J].

Alex, K. D. ;

Pehek, E. A. .

PHARMACOLOGY & THERAPEUTICS, 2007, 113 (02) :296-320

[2]

Allan AM, 2001, PSYCHOPHARMACOLOGY, V158, P18

[3] Antiamnesic Effect of B. monniera on L-NNA Induced Amnesia Involves Calmodulin [J].

Anand, Akshay ;

Saraf, Manish Kumar ;

Prabhakar, Sudesh .

NEUROCHEMICAL RESEARCH, 2010, 35 (08) :1172-1181

[4]

Angers A, 1998, J NEUROSCI, V18, P5586

[5]

BLANDINA P, 1989, J PHARMACOL EXP THER, V251, P803

[6]

Bures J., 1983, TECHNIQUES BASIC EXP, P148

[7]

Byrne JH, 1996, J NEUROSCI, V16, P425

[8] THE 5-HT3, RECEPTOR AGONIST 1-(M-CHLOROPHENYL)-BIGUANIDE INTERACTS WITH THE DOPAMINE TRANSPORTER IN RAT-BRAIN SYNAPTOSOMES [J].

CAMPBELL, AD ;

WOMER, DE ;

SIMON, JR .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1995, 290 (02) :157-162

[9] Genomic analysis of serotonin receptors in learning and memory [J].

Cavallaro, Sebastiano .

BEHAVIOURAL BRAIN RESEARCH, 2008, 195 (01) :2-6

[10] Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells zby a single tube RT-PCR [J].

Chamizo, C ;

Rubio, JM ;

Moreno, J ;

Alvar, J .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2001, 83 (3-4) :191-202

← 1 2 3 4 5 6 7 →