Microwave-Assisted Decarboxylative Three-Component Coupling of a 2-Oxoacetic Acid, an Amine, and an Alkyne

被引：51

作者：

Feng, Huangdi ^{[1
,2
]}

Ermolat'ev, Denis S. ^{[1
]}

Song, Gonghua ^{[2
]}

Van der Eycken, Erik V. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Chem, LOMAC, B-3001 Heverlee, Belgium

[2] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 18期

关键词：

TERMINAL ALKYNES; DIASTEREOSELECTIVE SYNTHESIS; CARBOXYLIC-ACIDS; DIRECT ADDITION; PROPARGYLAMINES; ALDEHYDE; GOLD; ACCESS; ACYLATION; CATALYSTS;

D O I：

10.1021/jo2013725

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient microwave-assisted decarboxylative three-component coupling of a 2-oxoacetic acid, an amine, and an alkyne (OA(2)-coulpling) has been developed. This new multicomponent coupling constitutes an efficient approach for the synthesis of polysubstituted propargylamines in the presence of a catalytic amount of copper(I) catalyst.

引用

页码：7608 / 7613

页数：6

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