The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model

被引：9
|
作者：
Kahng, Jimin [1 ]
Kim, Tae Kwan [2 ]
Chung, Eun Yong [2 ]
Kim, Yee Suk [2 ]
Moon, Jeong Yeon [2 ]
机构：
[1] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Lab Med, Bucheon, South Korea
[2] Bucheon St Marys Hosp, Dept Anaesthesia & Pain Med, Bucheon, Kyunggido, South Korea
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2015年 / 43卷 / 03期
关键词：
Thioctic acid; neuropathy; pain; vincristine; ALPHA-LIPOIC ACID; INDUCED PAINFUL NEUROPATHY; INDUCED PERIPHERAL NEUROPATHY; OXIDATIVE STRESS; MECHANICAL ALLODYNIA; OXALIPLATIN; INVOLVEMENT; MORPHINE; DRUGS;
D O I：
10.1177/0300060515569287
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats. Methods Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180min after treatment. Results Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose. Conclusion Thioctic acid may be an effective treatment for vincristine-induced neuropathy.
引用
收藏
页码：350 / 355
页数：6
相关论文
共 50 条
  • [31] Netazepide, an Antagonist of Cholecystokinin Type 2 Receptor, Prevents Vincristine-Induced Sensory Neuropathy in Mice
    Bernard, Amandine
    Mroue, Mohamad
    Bourthoumieu, Sylvie
    Boyce, Malcolm
    Richard, Laurence
    Sturtz, Franck
    Demiot, Claire
    Danigo, Aurore
    PHARMACEUTICALS, 2024, 17 (02)
  • [32] Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy
    Ozyurek, Hamit
    Turker, Hande
    Akbalik, Mehtap
    Bayrak, Ayse Oytun
    Ince, Hulya
    Duru, Feride
    PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2007, 24 (5-8) : 447 - 452
  • [33] Hydroethanolic Extract of Capparis spinosa Amends Vincristine-Induced Peripheral Neuropathy in Rats
    Sahranavard, Shamim
    Khoramjouy, Mona
    Seyyedan, Mina
    Faizi, Mehrdad
    Mosaddegh, Mahmoud
    JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES, 2024, 12 (01):
  • [34] The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice
    Zhu, Jianchun
    Li, Yang
    Liang, Jinghui
    Li, Jingxin
    Huang, Kai
    Li, Jing
    Liu, Chuanyong
    TOXICOLOGY LETTERS, 2021, 340 : 67 - 76
  • [35] Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats
    Muthuraman, Arunachalam
    Singh, Nirmal
    JOURNAL OF NATURAL MEDICINES, 2011, 65 (3-4) : 480 - 487
  • [36] Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review
    Madsen, Marie Lindhard
    Due, Hanne
    Ejskjaer, Niels
    Jensen, Paw
    Madsen, Jakob
    Dybkaer, Karen
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2019, 84 (03) : 471 - 485
  • [37] Obesity as a Potential Risk Factor for Vincristine-induced Peripheral Neuropathy
    Sajdyk, Tammy J.
    Boyle, Frances A.
    Foran, Kaitlin S.
    Tong, Yan
    Pandya, Pankita
    Smith, Ellen M. L.
    Ho, Richard H.
    Wells, Elizabeth
    Renbarger, Jamie L.
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2020, 42 (07) : E637 - E640
  • [38] Glutamine for the treatment of vincristine-induced neuropathy in children and adolescents with cancer
    Sands, Stephen
    Ladas, Elena J.
    Kelly, Kara M.
    Weiner, Michael
    Lin, Meiko
    Ndao, Deborah Hughes
    Dave, Amie
    Vahdat, Linda T.
    Bender, Julia Glade
    SUPPORTIVE CARE IN CANCER, 2017, 25 (03) : 701 - 708
  • [39] Altered temporal pattern of evoked afferent activity in a rat model of vincristine-induced painful peripheral neuropathy
    Tanner, KD
    Reichling, DB
    Gear, RW
    Paul, SM
    Levine, JD
    NEUROSCIENCE, 2003, 118 (03) : 809 - 817
  • [40] Neuroprotective Effect of Matrine in Mouse Model of Vincristine-Induced Neuropathic Pain
    Gong, Shuai-Shuai
    Li, Yu-Xiang
    Zhang, Meng-Ting
    Du, Juan
    Ma, Peng-Sheng
    Yao, Wan-Xia
    Zhou, Ru
    Niu, Yang
    Sun, Tao
    Yu, Jian-Qiang
    NEUROCHEMICAL RESEARCH, 2016, 41 (11) : 3147 - 3159
12345