META-ANALYSIS OF STEM CELL TRANSPLANTATION FOR REFLEX HYPERSENSITIVITY AFTER SPINAL CORD INJURY

被引：8
作者：
Chen, Xuemei [1 ]
Xue, Bohan [1 ]
Li, Yuping [1 ]
Song, Chunhua [2 ]
Jia, Peijun [1 ]
Ren, Xiuhua [1 ]
Zang, Weidong [1 ]
Wang, Jian [1 ,3 ]
机构：
[1] Zhengzhou Univ, Dept Human Anat, Basic Med Coll, Zhengzhou 450001, Henan, Peoples R China
[2] Zhengzhou Univ, Dept Epidemiol & Stat, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
[3] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA
来源：
NEUROSCIENCE | 2017年 / 363卷
基金：
中国国家自然科学基金; 美国国家卫生研究院;
关键词：
spinal cord injury; stem cells; neuropathic pain; meta-analysis; TRAUMATIC BRAIN-INJURY; QUALITY-OF-LIFE; NEUROPATHIC PAIN; FUNCTIONAL RECOVERY; SCHWANN-CELLS; PRECURSORS; ALLODYNIA; CONTUSION; REPAIR;
D O I：
10.1016/j.neuroscience.2017.06.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Stem cells have been used in novel therapeutic strategies for spinal cord injury (SCI), but the effect of stem cell transplantation on neuropathic pain after SCI is unclear. The current meta-analysis evaluates the effects of stem cell transplantation on neuropathic pain after SCI. We first conducted online searches of PubMed, Web of Science, China Academic Journals Full-text Database, and Wanfang Data for randomized controlled trials that compared stem cell transplantation and vehicle treatments in rodent models of neuropathic pain after SCI. Quality assessment was performed using Cochrane Reviewer's Handbook 5.1.0, and meta-analysis was conducted with RevMan 5.3. Then, we developed a rat model of SCI and transplanted bone marrow mesenchymal stem cells to verify meta-analysis results. Twelve randomized, controlled trials (n = 354 total animals) were included in our meta-analysis and divided by subgroups, including species, timing of behavioral measurements, and transplantation time after SCI. Subgroup analysis of these 12 studies indicated that stem cell-treated animals had a higher mechanical reflex threshold than vehicle groups, with a significant difference in both rats and mice. The thermal withdrawal latency showed the same results in mouse subgroups, but not in rat subgroups. In addition, mesenchymal stem cell transplantation was an effective treatment for mechanical, but not thermal reflex hypersensitivity relief in rats. Transplantation showed a positive effect when carried out at 3 or 7 days post-SCI. Stem cell transplantation alleviates mechanical reflex hypersensitivity in rats and mice and thermal reflex hypersensitivity in mice after SCI. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：66 / 75
页数：10
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