Assembly and operation of bacterial tripartite multidrug efflux pumps

被引：60
|
作者：
Du, Dijun [1 ]
van Veen, Hendrik W. [2 ]
Luisi, Ben F. [1 ]
机构：
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
[2] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England
来源：
TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 05期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金; 英国医学研究理事会;
关键词：
membrane proteins; drug resistance; transport mechanism; MAJOR FACILITATOR SUPERFAMILY; PERIPLASMIC ADAPTER PROTEIN; OUTER-MEMBRANE PROTEIN; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; ATP-BINDING; TIP REGION; PSEUDOMONAS-AERUGINOSA; ALTERNATING ACCESS;
D O I：
10.1016/j.tim.2015.01.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microorganisms encode several classes of transmembrane pumps that can expel an enormous range of toxic substances, thereby improving their fitness in harsh environments and contributing to resistance against antimicrobial agents. In Gram-negative bacteria these pumps can take the form of tripartite assemblies that actively efflux drugs and other harmful compounds across the cell envelope. We describe recent structural and functional data that have provided insights into the transport mechanisms of these intricate molecular machines.
引用
收藏
页码：311 / 319
页数：9
相关论文
共 50 条
  • [21] Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump
    Janganan, Thamarai K.
    Bavro, Vassiliy N.
    Zhang, Li
    Borges-Walmsley, Maria Ines
    Walmsley, Adrian R.
    MOLECULAR MICROBIOLOGY, 2013, 88 (03) : 590 - 602
  • [22] A data-driven approach to modeling the tripartite structure of multidrug resistance efflux pumps
    Phillips, Joshua L.
    Gnanakaran, S.
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2015, 83 (01) : 46 - 65
  • [23] Assembly and transport mechanism of tripartite drug efflux systems
    Misra, Rajeev
    Bavro, Vassiliy N.
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2009, 1794 (05): : 817 - 825
  • [24] Evidence for the Assembly of a Bacterial Tripartite Multidrug Pump with a Stoichiometry of 3:6:3
    Janganan, Thamarai K.
    Bavro, Vassiliy N.
    Zhang, Li
    Matak-Vinkovic, Dijana
    Barrera, Nelson P.
    Venien-Bryan, Catherine
    Robinson, Carol V.
    Borges-Walmsley, Maria Ines
    Walmsley, Adrian R.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (30) : 26900 - 26912
  • [25] How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps
    Blair, Jessica M. A.
    Piddock, Laura J. V.
    MBIO, 2016, 7 (04):
  • [26] Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence
    Alcalde-Rico, Manuel
    Hernando-Amado, Sara
    Blanco, Paula
    Martinez, Jose L.
    FRONTIERS IN MICROBIOLOGY, 2016, 7
  • [27] Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
    Nishino, Kunihiko
    Yamasaki, Seiji
    Nakashima, Ryosuke
    Zwama, Martijn
    Hayashi-Nishino, Mitsuko
    FRONTIERS IN MICROBIOLOGY, 2021, 12
  • [28] Sequence- and structure-based computational analyses of Gram-negative tripartite efflux pumps in the context of bacterial membranes
    Travers, Timothy
    Wang, Katherine J.
    Lopez, Cesar A.
    Gnanakaran, S.
    RESEARCH IN MICROBIOLOGY, 2018, 169 (7-8) : 414 - 424
  • [29] Funnel-like Hexameric Assembly of the Periplasmic Adapter Protein in the Tripartite Multidrug Efflux Pump in Gram-negative Bacteria
    Xu, Yongbin
    Lee, Minho
    Moeller, Arne
    Song, Saemee
    Yoon, Bo-Young
    Kim, Hong-Man
    Jun, So-Young
    Lee, Kangseok
    Ha, Nam-Chul
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (20) : 17910 - 17920
  • [30] Host-Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
    Pasqua, Martina
    Bonaccorsi di Patti, Maria Carmela
    Fanelli, Giulia
    Utsumi, Ryutaro
    Eguchi, Yoko
    Trirocco, Rita
    Prosseda, Gianni
    Grossi, Milena
    Colonna, Bianca
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
12345