Mechanistic insights into the gold-catalyzed cycloisomerization of bromoallenyl ketones: Ligand-controlled regioselectivity

被引：218

作者：

Xia, Yuanzhi ^{[1
,2
]}

Dudnik, Alexander S. ^{[3
]}

Gevorgyan, Vladimir ^{[3
]}

Li, Yahong ^{[1
,2
]}

机构：

[1] Suzhou Univ, Dept Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215006, Peoples R China

[2] Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Peoples R China

[3] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 22期

关键词：

D O I：

10.1021/ja802144t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Through computational and experimental studies, the mechanisms of gold-catalyzed cycloisomerization of bromoallenyl ketones in toluene have been elucidated. The divergent 1,2-migrations for the Au(I)- and Au(III)-catalyzed reactions have been investigated, and the results confirmed that the regiochemistry is ligand-dependent in cases of Au(PR3)L (L = Cl, OTf, BF4, and SbF6) catalysts.

引用

页码：6940 / +

页数：3

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