Paracetamol-induced acute kidney injury in the absence of acute liver injury: a retrospective cohort study

被引：1
|
作者：
Daoud, Alaa [1 ,2 ,3 ,4 ,5 ,6 ]
Dalhoff, Kim Peder [1 ,2 ,3 ]
Petersen, Tonny Studsgaard [1 ,2 ,3 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Bispebjerg & Frederiksberg Hosp, Dept Clin Pharmacol, Copenhagen, Denmark
[3] Copenhagen Univ Hosp, Bispebjerg & Frederiksberg Hosp, Danish Poison Informat Ctr, Copenhagen, Denmark
[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark
[5] Bispebjerg & Frederiksberg Hosp, Dept Clin Pharmacol, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
[6] Bispebjerg & Frederiksberg Hosp, Danish Poison Informat Ctr, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
来源：
TOXICOLOGY COMMUNICATIONS | 2022年 / 6卷 / 01期
关键词：
Paracetamol; acetaminophen; poisoning; acetylcysteine; acute kidney injury; retrospective cohort study; ACUTE-RENAL-FAILURE; OVERDOSE;
D O I：
10.1080/24734306.2022.2117941
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Paracetamol-induced nephrotoxicity in the absence of hepatotoxicity is only described in a few studies. The aim of this retrospective cohort study with data from the Capital Region of Denmark 2010-2017, was to examine the incidence of possible paracetamol-induced nephrotoxicity in absence of hepatotoxicity. Only one out of 5,827 admissions (0.02%) included in the study developed clinically relevant acute kidney injury (AKI) that could be attributed to paracetamol in absence of acute liver injury. This study demonstrates that clinically relevant AKI due to paracetamol overdose rarely occurs without concomitant hepatic injury when excluding other prerenal, renal, and postrenal causes of renal dysfunction, NAC interference and chronic kidney injury.
引用
收藏
页码：97 / 100
页数：4
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