Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs

被引：23

作者：

Guo, Yuming ^{[1
,2
]}

Jia, Weili ^{[1
]}

Li, Han ^{[1
]}

Shi, Weike ^{[1
]}

Zhang, Jie ^{[1
]}

Feng, Jing ^{[1
]}

Yang, Lin ^{[1
,2
]}

机构：

[1] Henan Normal Univ, Minist Educ, Key Lab Green Chem Media & React, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Xinxiang 453007, Henan, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Green Chem Media & React, Xinxiang 453007, Henan, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 34期

基金：

中国国家自然科学基金;

关键词：

MESOPOROUS SILICA NANOPARTICLES; POTENTIAL APPLICATIONS; CANCER-CELLS; DELIVERY; CONSTRUCTION; NANOCARRIERS; NANOSPHERES; ACID;

D O I：

10.1039/c6tb01483f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Biocompatible hybrid hollow spheres of calcium carbonate/folate with both mesopores and macropores were synthesized using a facile green approach based on Ostwald ripening. The porous hollow spheres were efficiently loaded with doxorubicin, which they were then able to release in a pH-responsive and sustained manner for the targeted treatment of human cancer cells.

引用

收藏

页码：5650 / 5653

页数：4

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