A bispecific antibody composed of a nonneutralizing antibody to the gp41 immunodominant region and an anti-CD89 antibody directs broad human immunodeficiency virus destruction by neutrophils

被引：27
作者：
Duval, Mark [1 ,2 ]
Posner, Marshall R. [1 ,2 ]
Cavacini, Lisa A. [1 ,2 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Dept Med, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
来源：
JOURNAL OF VIROLOGY | 2008年 / 82卷 / 09期
关键词：
D O I：
10.1128/JVI.02499-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In addition to the direct neutralization of virus, there is a broader potential for antibody-mediated inhibition of human immunodeficiency virus (HIV) by targeting HIV to effector cells. We demonstrate here that a bispecific antibody incorporating a broadly reactive anti-gp41. antibody, F240, and an anti-IgA receptor (CD89) antibody is effective at directing neutrophils to destroy HIV. Not only are neutrophils the predominant type of white blood cells and very efficient at mediating cell cytotoxicity, they are relatively resistant to infection with HIV. Therefore, they represent a significant weapon against infection if they can be directed and armed to destroy HIV and infected cells.
引用
收藏
页码：4671 / 4674
页数：4
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