Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins

被引：47
作者：
Qian, Jiang [1 ]
Klomsiri, Chananat [2 ]
Wright, Marcus W. [3 ]
King, S. Bruce [3 ]
Tsang, Allen W. [1 ]
Poole, Leslie B. [2 ]
Furdui, Cristina M. [1 ]
机构：
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Sect Mol Med, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA
[3] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 32期
基金：
美国国家科学基金会;
关键词：
CHEMICAL PROBES; DIMEDONE;
D O I：
10.1039/c1cc12127h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.
引用
收藏
页码：9203 / 9205
页数：3
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