A NEW PHENOLIC GLYCOSIDE FROM Viburnum melanocarpum FRUITS AND ITS α-GLUCOSIDASE INHIBITORY ACTIVITY

被引：3

作者：

Zhao, Zi-Yang ^{[1
]}

Chen, Jia ^{[1
]}

Shen, Jie ^{[1
]}

Shao, Jian-Hua ^{[1
]}

Huang, Xu-Hua ^{[1
]}

Zhao, Chun-Chao ^{[1
]}

机构：

[1] Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou 225009, Jiangsu, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Viburnum melanocarpum; phenolic glycoside; alpha-glucosidase inhibitory activity;

D O I：

10.1007/s10600-020-02998-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new phenolic glycoside 1, together with its enantiomer (2), was isolated from the ethanolic extract of Viburnum melanocarpum P. S. Hsu fruits by repeated column chromatography. Its structure was identified as (7R,8S)-guaiacylglycerol 4-O-beta-D-(6-O-vanilloyl)glucopyranoside (1) by spectroscopic data (H-1 NMR, C-13 NMR, HSQC, HMBC, and ORD) and chemical methods. In the intestinal alpha-glucosidase inhibitory activity test, compound 1 exhibited potent inhibitory activity with IC50 value of 10.04 mu M in comparison with the positive control acarbose (IC50 16.37 mu M).

引用

页码：246 / 248

页数：3

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