Synthesis and evaluation of influenza virus sialidase inhibitory activity of hinokiflavone-sialic acid conjugates

被引：0
|
作者：
Miki, Kazuhiko [5 ]
Nagai, Takayuki [1 ,2 ,3 ]
Nakamura, Takayuki [5 ]
Tuji, Mitsuru [5 ]
Koyama, Kiyotaka [5 ]
Kinoshita, Kaoru [5 ]
Furuhata, Kimio [4 ]
Yamada, Haruki
Takahashi, Kunio [5 ]
机构：
[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan
[2] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan
[3] Kitasato Inst, Oriental Med Res Ctr, Minato Ku, Tokyo 1088642, Japan
[4] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088642, Japan
[5] Meiji Pharm Univ, Dept Pharmacognosy & Phytochem, Kiyose, Tokyo 2048588, Japan
来源：
HETEROCYCLES | 2008年 / 75卷 / 04期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The known biflavonoid, hinokiflavone (1) was isolated from the leaves of Metasequoia glyptostroboides Hu et Cheng and displayed influenza A and B virus sialidase inhibitory activity. The unnatural glycoconjugate, hinokiflavone-sialic acid (8) was synthesized and exhibited more potent inhibitory activity.
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页码：879 / 885
页数：7
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