Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer's disease

被引：8
|
作者：
Wang, Qing [1 ]
Xie, Chunming [1 ,2 ,3 ]
机构：
[1] Southeast Univ, Sch Med, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing, Peoples R China
[2] Southeast Univ, Affiliated ZhongDa Hosp, Inst Neuropsychiat, Nanjing, Peoples R China
[3] Southeast Univ, Key Lab Dev Genes & Human Dis, Nanjing, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷
基金：
中国国家自然科学基金;
关键词：
neuroinflammation; Alzheimer's disease; microglial activation; tau pathology; PET imaging; HIGH-AFFINITY; PATHOLOGY; MODEL;
D O I：
10.3389/fnins.2022.951128
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
[No abstract available]
引用
收藏
页数：5
相关论文
共 50 条
  • [31] New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease
    Zhang, Feng
    Zhong, Ru-jia
    Cheng, Cheng
    Li, Song
    Le, Wei-dong
    ACTA PHARMACOLOGICA SINICA, 2021, 42 (09) : 1382 - 1389
  • [32] Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer's Disease
    Torres, Angie K.
    Jara, Claudia
    Park-Kang, Han S.
    Polanco, Catalina M.
    Tapia, Diego
    Alarcon, Fabian
    de la Pena, Adely
    Llanquinao, Jesus
    Vargas-Mardones, Gabriela
    Indo, Javiera A.
    Inestrosa, Nibaldo C.
    Tapia-Rojas, Cheril
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 84 (04) : 1391 - 1414
  • [33] Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease
    Ferrari-Souza, Joao Pedro
    Ferreira, Pamela C. L.
    Bellaver, Bruna
    Tissot, Cecile
    Wang, Yi-Ting
    Leffa, Douglas T.
    Brum, Wagner S.
    Benedet, Andrea L.
    Ashton, Nicholas J.
    De Bastiani, Marco Antonio
    Rocha, Andreia
    Therriault, Joseph
    Lussier, Firoza Z.
    Chamoun, Mira
    Servaes, Stijn
    Bezgin, Gleb
    Kang, Min Su
    Stevenson, Jenna
    Rahmouni, Nesrine
    Pallen, Vanessa
    Poltronetti, Nina Margherita
    Klunk, William E.
    Tudorascu, Dana L.
    Cohen, Ann D.
    Villemagne, Victor L.
    Gauthier, Serge
    Blennow, Kaj
    Zetterberg, Henrik
    Souza, Diogo O.
    Karikari, Thomas K.
    Zimmer, Eduardo R.
    Rosa-Neto, Pedro
    Pascoal, Tharick A.
    MOLECULAR PSYCHIATRY, 2022, 27 (11) : 4781 - 4789
  • [34] Temporal association patterns and dynamics of amyloid-β and tau in Alzheimer's disease
    Ower, Alison K.
    Hadjichrysanthou, Christoforos
    Gras, Luuk
    Goudsmit, Jaap
    Anderson, Roy M.
    de Wolf, Frank
    EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2018, 33 (07) : 657 - 666
  • [35] Pathogenesis of Alzheimer's Disease: Role of Amyloid-β and Hyperphosphorylated Tau Protein
    Sajjad, Rabia
    Arif, Rawaba
    Shah, A. A.
    Manzoor, I.
    Mustafa, G.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 80 (04) : 581 - 591
  • [36] Amyloid- Increases Tau by Mediating Sirtuin 3 in Alzheimer's Disease
    Yin, Junxiang
    Han, Pengcheng
    Song, Melissa
    Nielsen, Megan
    Beach, Thomas G.
    Serrano, Geidy E.
    Liang, Winnie S.
    Caselli, Richard J.
    Shi, Jiong
    MOLECULAR NEUROBIOLOGY, 2018, 55 (11) : 8592 - 8601
  • [37] Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease
    Markus Mandler
    Lauren Walker
    Radmila Santic
    Peter Hanson
    Ajeet Rijal Upadhaya
    Sean J. Colloby
    Christopher M. Morris
    Dietmar R. Thal
    Alan J. Thomas
    Achim Schneeberger
    Johannes Attems
    Acta Neuropathologica, 2014, 128 : 67 - 79
  • [38] Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease
    Yu, Meichen
    Risacher, Shannon L.
    Nho, Kwangsik T.
    Wen, Qiuting
    Oblak, Adrian L.
    Unverzagt, Frederick W.
    Apostolova, Liana G.
    Farlow, Martin R.
    Brosch, Jared R.
    Clark, David G.
    Wang, Sophia
    Deardorff, Rachael
    Wu, Yu-Chien
    Gao, Sujuan
    Sporns, Olaf
    Saykin, Andrew J.
    CELL REPORTS, 2024, 43 (02):
  • [39] Amyloid-β-independent regulators of tau pathology in Alzheimer disease
    Rik van der Kant
    Lawrence S. B. Goldstein
    Rik Ossenkoppele
    Nature Reviews Neuroscience, 2020, 21 : 21 - 35
  • [40] Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis
    Bloom, George S.
    JAMA NEUROLOGY, 2014, 71 (04) : 505 - 508
12345