Stimulating severe COVID-19: the potential role of GM-CSF antagonism

被引：9

作者：

Leavis, Helen L. ^{[1
]}

van de Veerdonk, Frank L. ^{[2
]}

Murthy, Srinivas ^{[3
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[3] Univ British Columbia, Fac Med, Vancouver, BC V6H 3V4, Canada

来源：

LANCET RESPIRATORY MEDICINE | 2022年 / 10卷 / 03期

关键词：

D O I：

10.1016/S2213-2600(21)00539-7

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

引用

页码：223 / 224

页数：2

共 10 条

[1] Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial [J].

Cremer, Paul C. ;

Abbate, Antonio ;

Hudock, Kristin ;

McWilliams, Carla ;

Mehta, Jinesh ;

Chang, Steven Y. ;

Sheng, Calvin C. ;

Van Tassell, Benjamin ;

Bonaventura, Aldo ;

Vecchie, Alessandra ;

Carey, Brenna ;

Wang, Qiuqing ;

Wolski, Katherine E. ;

Rajendram, Prabalini ;

Duggal, Abhijit ;

Wang, Tisha S. ;

Paolini, John F. ;

Trapnell, Bruce C. .

LANCET RHEUMATOLOGY, 2021, 3 (06) :E410-E418

[2]

Gordon AC, 2021, NEW ENGL J MED, V384, P1491, DOI [10.1056/NEJMoa2100433, 10.1056/NEJMc2108482]

[3]

Horby PW, 2021, LANCET, V397, P1637, DOI 10.1016/S0140-6736(21)00676-0

[4] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (vol 395, pg 497, 2020) [J].

Huang, C. ;

Wang, Y. ;

Li, X. .

LANCET, 2020, 395 (10223) :496-496

[5] GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches [J].

Lang, Frederick M. ;

Lee, Kevin M-C ;

Teijaro, John R. ;

Becher, Burkhard ;

Hamilton, John A. .

NATURE REVIEWS IMMUNOLOGY, 2020, 20 (08) :507-514

[6]

Patel J., 2021, RANDOMIZED TRIAL OTI, DOI [10.1101/2021.04.14.21255475, DOI 10.1101/2021.04.14.21255475]

[7] Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know [J].

Shi, YF ;

Liu, CH ;

Roberts, AI ;

Das, JT ;

Xu, GW ;

Ren, GW ;

Zhang, YY ;

Zhang, LY ;

Yuan, ZR ;

Tan, HSW ;

Das, GH ;

Devadas, S .

CELL RESEARCH, 2006, 16 (02) :126-133

[8] Pivotal Roles of GM-CSF in Autoimmunity and Inflammation [J].

Shiomi, Aoi ;

Usui, Takashi .

MEDIATORS OF INFLAMMATION, 2015, 2015

[9] Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial [J].

Temesgen, Zelalem ;

Burger, Charles D. ;

Baker, Jason ;

Polk, Christopher ;

Libertin, Claudia R. ;

Kelley, Colleen F. ;

Marconi, Vincent C. ;

Orenstein, Robert ;

Catterson, Victoria M. ;

Aronstein, William S. ;

Durrant, Cameron ;

Chappell, Dale ;

Ahmed, Omar ;

Chappell, Gabrielle ;

Badley, Andrew D. .

LANCET RESPIRATORY MEDICINE, 2022, 10 (03) :237-246

[10] The immunopathology of sepsis and potential therapeutic targets [J].

van der Poll, Tom ;

van de Veerdonk, Frank L. ;

Scicluna, Brendon P. ;

Netea, Mihai G. .

NATURE REVIEWS IMMUNOLOGY, 2017, 17 (07) :407-420

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