Coupling Reaction of Cu-Based Carbene and Nitroso Radical: A Tandem Reaction To Construct Isoxazolines

被引：49

作者：

Chen, Rongxiang ^{[1
]}

Zhao, Yanwei ^{[1
]}

Fang, Shangwen ^{[1
]}

Long, Wenhao ^{[1
]}

Sun, Hongmei ^{[1
]}

Wan, Xiaobing ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 21期

关键词：

TERT-BUTYL NITRITE; CO(II)-BASED METALLORADICAL CATALYSIS; BETA-HYDROXY KETONES; GAMMA-AMINO KETONES; DIAZO-COMPOUNDS; H FUNCTIONALIZATION; FACILE SYNTHESIS; BOND FORMATION; UNACTIVATED ALKENES; DIRECT CONVERSION;

D O I：

10.1021/acs.orglett.7b02885

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this letter, an unprecedented cross-coupling reaction between copper carbene and nitroso radical has been developed: This radical-carbene coupling reaction (RCC reaction) offers a novel approach for the preparation of various isoxazolines, which features the construction of C-C, C-O, and C=N bonds in a one-pot process. The synthetic utility of our method is further enhanced by its mild reaction conditions, wide substrate scope, and simple procedures.

引用

页码：5896 / 5899

页数：4

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