Traditional antimalarials and the development of novel antimalarial drugs

被引:64
作者
Wright, CW [1 ]
机构
[1] Univ Bradford, Sch Pharm, Bradford BD7 1DP, W Yorkshire, England
关键词
antiplasmodial assays; artemisinin; cryptolepine; quassinoids; traditional antimalarials;
D O I
10.1016/j.jep.2005.05.012
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Malaria continues to be a major cause of mortality and morbidity especially throughout the developing world. In the last 25 years or so a number of significant advances have been made that have the potential to make a major contribution to the control of this disease. The discovery of artemisinin and its analogues as potent antimalarial agents have been of immense importance and the latter, as well as some other selected developments are outlined in this brief review. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:67 / 71
页数:5
相关论文
共 22 条
[1]   The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells [J].
Bonjean, K ;
De Pauw-Gillet, MC ;
Defresne, MP ;
Colson, P ;
Houssier, C ;
Dassonneville, L ;
Bailly, C ;
Greimers, R ;
Wright, C ;
Quetin-Leclercq, J ;
Tits, M ;
Angenot, L .
BIOCHEMISTRY, 1998, 37 (15) :5136-5146
[2]  
CORONA MRC, 2000, CURR OPIN ANTIINFECT, V2, P47
[3]   QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].
DESJARDINS, RE ;
CANFIELD, CJ ;
HAYNES, JD ;
CHULAY, JD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718
[4]   Artemisinins target the SERCA of Plasmodium falciparum [J].
Eckstein-Ludwig, U ;
Webb, RJ ;
van Goethem, IDA ;
East, JM ;
Lee, AG ;
Kimura, M ;
O'Neill, PM ;
Bray, PG ;
Ward, SA ;
Krishna, S .
NATURE, 2003, 424 (6951) :957-961
[5]   QUINOLINE ANTIMALARIAL-DRUGS INHIBIT SPONTANEOUS FORMATION OF BETA-HEMATIN (MALARIA PIGMENT) [J].
EGAN, TJ ;
ROSS, DC ;
ADAMS, PA .
FEBS LETTERS, 1994, 352 (01) :54-57
[6]   Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives [J].
Jonckers, THM ;
van Miert, S ;
Cimanga, K ;
Bailly, C ;
Colson, P ;
De Pauw-Gillet, MC ;
van den Heuvel, H ;
Claeys, M ;
Lemière, F ;
Esmans, EL ;
Rozenski, J ;
Quirijnen, L ;
Maes, L ;
Dommisse, R ;
Lemière, GLF ;
Vlietinck, A ;
Pieters, L .
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (16) :3497-3508
[7]   QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].
KLAYMAN, DL .
SCIENCE, 1985, 228 (4703) :1049-1055
[8]   PARASITE LACTATE-DEHYDROGENASE AS AN ASSAY FOR PLASMODIUM-FALCIPARUM DRUG-SENSITIVITY [J].
MAKLER, MT ;
RIES, JM ;
WILLIAMS, JA ;
BANCROFT, JE ;
PIPER, RC ;
GIBBINS, BL ;
HINRICHS, DJ .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 48 (06) :739-741
[9]  
MAZIER M, 2004, TRADITIONAL MED PLAN, P271
[10]   Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action [J].
Onyeibor, O ;
Croft, SL ;
Dodson, HI ;
Feiz-Haddad, M ;
Kendrick, H ;
Millington, NJ ;
Parapini, S ;
Phillips, RM ;
Seville, S ;
Shnyder, SD ;
Taramelli, D ;
Wright, CW .
JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (07) :2701-2709