Efficient and selective microwave-assisted copper-catalyzed synthesis of quinazolinone derivatives in aqueous

被引：20

作者：

Ke, Fang ^{[1
]}

Liu, Caiqin ^{[1
]}

Zhang, Peng ^{[1
]}

Xu, Jianhua ^{[1
]}

Chen, Xiaole ^{[1
]}

机构：

[1] Fujian Med Univ, Coll Pharm, Fuzhou 350004, Fujian, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 24期

关键词：

Catalysis; copper; microwave; quinazolinone; water; 4(3H)-QUINAZOLINONE DERIVATIVES; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; BOND FORMATION; ACIDS; CYCLIZATION; AMINES; QUINAZOLIN-4(3H)-ONES; HETEROCYCLES; INHIBITORS;

D O I：

10.1080/00397911.2018.1533974

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave- assisted copper-catalyzed cascade reactions between 2- halobenzoic acids and amidines to synthesize quinazolinone derivatives in water are reported. A variety of target products were obtained in good to excellent yields up to 94%. Its application was performed by the synthesis of 4-(1H- benzo[d]imidazol-2-ylthio)- 6methoxypteridine, which displayed significant anti- proliferation effect. [GRAPHICS] .

引用

页码：3089 / 3098

页数：10

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