Efficient and selective microwave-assisted copper-catalyzed synthesis of quinazolinone derivatives in aqueous

被引：20
|
作者：
Ke, Fang [1 ]
Liu, Caiqin [1 ]
Zhang, Peng [1 ]
Xu, Jianhua [1 ]
Chen, Xiaole [1 ]
机构：
[1] Fujian Med Univ, Coll Pharm, Fuzhou 350004, Fujian, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 24期
关键词：
Catalysis; copper; microwave; quinazolinone; water; 4(3H)-QUINAZOLINONE DERIVATIVES; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; BOND FORMATION; ACIDS; CYCLIZATION; AMINES; QUINAZOLIN-4(3H)-ONES; HETEROCYCLES; INHIBITORS;
D O I：
10.1080/00397911.2018.1533974
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Microwave- assisted copper-catalyzed cascade reactions between 2- halobenzoic acids and amidines to synthesize quinazolinone derivatives in water are reported. A variety of target products were obtained in good to excellent yields up to 94%. Its application was performed by the synthesis of 4-(1H- benzo[d]imidazol-2-ylthio)- 6methoxypteridine, which displayed significant anti- proliferation effect. [GRAPHICS] .
引用
收藏
页码：3089 / 3098
页数：10
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