Balancing reactive oxygen species generation by rebooting gut microbiota

被引:48
作者
Singh, Vandna [1 ]
Ahlawat, Shruti [2 ,3 ]
Mohan, Hari [1 ]
Gill, Sarvajeet Singh [4 ]
Sharma, Krishna Kant [2 ]
机构
[1] Maharshi Dayanand Univ, Dept Med Biotechnol, Rohtak, Haryana, India
[2] Maharshi Dayanand Univ, Dept Microbiol, Lab Enzymol & Recombinant DNA Technol, Rohtak 124001, Haryana, India
[3] SGT Univ, Gurugram, India
[4] Maharshi Dayanand Univ, Dept Plant Biotechnol, Rohtak, Haryana, India
关键词
dysbiosis; faecal microbiota transplantation; gut microbiota; inflammatory bowel disease; probiotics; reactive oxygen species; KETOGLUTARATE DEHYDROGENASE COMPLEX; OXIDATIVE STRESS; LACTOBACILLUS-PLANTARUM; EPITHELIAL BARRIER; ESCHERICHIA-COLI; IMMUNE-RESPONSE; NADPH OXIDASES; IN-VITRO; ROS; PROBIOTICS;
D O I
10.1111/jam.15504
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Reactive oxygen species (ROS; free radical form O-2(center dot-), superoxide radical; OH center dot, hydroxyl radical; ROO center dot, peroxyl; RO center dot, alkoxyl and non-radical form O-1(2), singlet oxygen; H2O2, hydrogen peroxide) are inevitable companions of aerobic life with crucial role in gut health. But, overwhelming production of ROS can cause serious damage to biomolecules. In this review, we have discussed several sources of ROS production that can be beneficial or dangerous to the human gut. Micro-organisms, organelles and enzymes play crucial role in ROS generation, where NOX1 is the main intestinal enzyme, which produce ROS in the intestine epithelial cells. Previous studies have reported that probiotics play significant role in gut homeostasis by checking the ROS generation, maintaining the antioxidant level, immune system and barrier protection. With current knowledge, we have critically analysed the available literature and presented the outcome in the form of bubble maps to suggest that the probiotics help in controlling the ROS-specific intestinal diseases, such as inflammatory bowel disease (IBD) and colon cancer. Finally, it has been concluded that rebooting of the gut microbiota with probiotics, postbiotics or faecal microbiota transplantation (FMT) can have crucial implications in the structuring of gut communities for the personalized management of the gastrointestinal (GI) diseases.
引用
收藏
页码:4112 / 4129
页数:18
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