The Phenomenon of Evolutionary "De Novo Generation" of Genes

被引:2
|
作者
Cherezov, R. O. [1 ]
Vorontsova, Ju E. [1 ]
Simonova, O. B. [1 ]
机构
[1] Russian Acad Sci, Koltzov Inst Dev Biol, Moscow 119334, Russia
基金
俄罗斯基础研究基金会;
关键词
gene; evolution; de novo; DROSOPHILA-MELANOGASTER; RAPID EVOLUTION; GENOME; TRANSCRIPTION; ORIGIN; BIRTH; PROTEINS; TRANSLATION; INTEGRATION; ENHANCERS;
D O I
10.1134/S1062360421060035
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Evolutionary biologists have always been interested in the origin and evolution of new genes. The most obvious mechanisms of their formation are various types of chromosomal and intergenic rearrangements, suggesting the use of existing genes as the source material. The possibility of the origin of a fully functional gene from noncoding DNA, i.e., de novo, was not rejected but it was practically considered as impossible until recently. Nevertheless, in 1996, after analysis of the yeast Saccharomyces cerevisiae genome, the first experimental evidence of the possibility of de novo gene formation was obtained. Ten years later, genes that do not have homologs, presumably having originated de novo, were found in Drosophila. The relatively high probability of the occurrence of genes de novo, estimated in bioinformatics studies, raised the interest in this topic and made the search for genes of this type relevant. Recently, the number of works devoted to the problem of the emergence of de novo genes in different organisms, including humans, is constantly growing, demystifying this phenomenon. Nevertheless, there are still many questions that require theoretical and practical research. This review is devoted to the problem of finding and characterizing genes that have arisen de novo, as well as to the proposed mechanisms of their occurrence.
引用
收藏
页码:390 / 400
页数:11
相关论文
共 50 条
  • [31] Revisiting the Evolutionary History of Pigs via De Novo Mutation Rate Estimation in A Three-generation Pedigree
    Mingpeng Zhang
    Qiang Yang
    Huashui Ai
    Lusheng Huang
    Genomics,Proteomics & Bioinformatics, 2022, (06) : 1040 - 1052
  • [32] EvoMS: An evolutionary tool to find de novo metabolic pathways
    Gerard, Matias F.
    Stegmayer, Georgina
    Milone, Diego H.
    BIOSYSTEMS, 2015, 134 : 43 - 47
  • [33] LEADD: Lamarckian evolutionary algorithm for de novo drug design
    Kerstjens, Alan
    De Winter, Hans
    JOURNAL OF CHEMINFORMATICS, 2022, 14 (01)
  • [34] LEADD: Lamarckian evolutionary algorithm for de novo drug design
    Alan Kerstjens
    Hans De Winter
    Journal of Cheminformatics, 14
  • [35] Virtual screening for bioactive molecules by evolutionary de novo design
    Schneider, G
    Clément-Chomienne, O
    Hilfiger, L
    Schneider, P
    Kirsch, S
    Böhm, HJ
    Neidhart, W
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2000, 39 (22) : 4130 - 4133
  • [36] Virtual screening for bioactive molecules by evolutionary de novo design
    Schneider, Gisbert
    Clement-Chomienne, Odile
    Hilfiger, Laurence
    Schneider, Petra
    Kirsch, Stefan
    Bohm, Hans-Joachim
    Neidhart, Werner
    Angewandte Chemie (International Edition in English), 2000, 39 (22): : 4130 - 4133
  • [37] De Novo Drug Design Using Multiobjective Evolutionary Graphs
    Nicolaou, Christos A.
    Apostolakis, Joannis
    Pattichis, Costas S.
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2009, 49 (02) : 295 - 307
  • [38] Evolutionary optimization of a de novo selected ATP binding protein
    Nilsson, M
    Stomel, J
    Chaput, JC
    BIOPOLYMERS, 2005, 80 (04) : 592 - 592
  • [39] De novo alpha satellite insertions and the evolutionary landscape of centromeres
    Giannuzzi, Giuliana
    Logsdon, Glennis
    Chatron, Nicolas
    Miller, Danny E.
    Reversat, Julie
    Munson, Katherine M.
    Hoekzema, Kendra
    Baker, Carl A.
    Sanlaville, Damien
    Eichler, Evan E.
    Schluth-Bolard, Caroline
    Reymond, Alexandre
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2022, 30 (SUPPL 1) : 81 - 81
  • [40] The origin and structural evolution of de novo genes in Drosophila
    Peng, Junhui
    Zhao, Li
    NATURE COMMUNICATIONS, 2024, 15 (01)