SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

被引：4

作者：

Wang, Yating ^{[1
]}

Abolhassani, Hassan ^{[1
]}

Hammarstrom, Lennart ^{[1
]}

Pan-Hammarstrom, Qiang ^{[1
]}

机构：

[1] Karolinska Inst, Dept Biosci & Nutr, SE-14183 Huddinge, Sweden

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2022年 / 54卷 / 06期

基金：

瑞典研究理事会; 欧盟地平线“2020”;

关键词：

COVID-19; DNA repair mechanism; inborn errors of immunity; primary immunodeficiency; CLASS-SWITCH RECOMBINATION; CYTIDINE DEAMINASE AID; STRAND BREAK REPAIR; LIGASE-IV COMPLEX; SOMATIC HYPERMUTATION; PRIMARY IMMUNODEFICIENCY; GENOMIC INSTABILITY; GROWTH-RETARDATION; RAG1; MUTATION; DEFICIENCY;

D O I：

10.3724/abbs.2022071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.

引用

页码：836 / 846

页数：11

共 155 条

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