SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

被引：4
作者：
Wang, Yating [1 ]
Abolhassani, Hassan [1 ]
Hammarstrom, Lennart [1 ]
Pan-Hammarstrom, Qiang [1 ]
机构：
[1] Karolinska Inst, Dept Biosci & Nutr, SE-14183 Huddinge, Sweden
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2022年 / 54卷 / 06期
基金：
瑞典研究理事会; 欧盟地平线“2020”;
关键词：
COVID-19; DNA repair mechanism; inborn errors of immunity; primary immunodeficiency; CLASS-SWITCH RECOMBINATION; CYTIDINE DEAMINASE AID; STRAND BREAK REPAIR; LIGASE-IV COMPLEX; SOMATIC HYPERMUTATION; PRIMARY IMMUNODEFICIENCY; GENOMIC INSTABILITY; GROWTH-RETARDATION; RAG1; MUTATION; DEFICIENCY;
D O I：
10.3724/abbs.2022071
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.
引用
收藏
页码：836 / 846
页数：11
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