Neural Control of Energy Balance: Translating Circuits to Therapies

被引：195
作者：
Gautron, Laurent [1 ]
Elmquist, Joel K. [1 ,2 ]
Williams, Kevin W. [1 ,3 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
[3] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA
来源：
CELL | 2015年 / 161卷 / 01期
关键词：
Y GASTRIC BYPASS; DIRECT-CURRENT STIMULATION; GLUCAGON-LIKE PEPTIDE-1; DEEP BRAIN-STIMULATION; CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE; REVERSES INSULIN-RESISTANCE; LATERAL HYPOTHALAMIC AREA; TYPE-2; DIABETES-MELLITUS; MELANOCORTIN; RECEPTORS; NEURONS REGULATE ENERGY;
D O I：
10.1016/j.cell.2015.02.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent insights into the neural circuits controlling energy balance and glucose homeostasis have rekindled the hope for development of novel treatments for obesity and diabetes. However, many therapies contribute relatively modest beneficial gains with accompanying side effects, and the mechanisms of action for other interventions remain undefined. This Review summarizes current knowledge linking the neural circuits regulating energy and glucose balance with current and potential pharmacotherapeutic and surgical interventions for the treatment of obesity and diabetes.
引用
收藏
页码：133 / 145
页数：13
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