Adipokines: The missing link between insulin resistance and obesity

被引：541
|
作者：
Antuna-Puente, B. [1 ,2 ]
Feve, B. [3 ,4 ]
Fellahi, S. [2 ]
Bastard, J. -P. [1 ,2 ]
机构：
[1] Univ Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
[2] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, France
[3] Univ Paris 11, Fac Med Bicetre, INSERM, U693, F-94720 Le Kremlin Bicetre, France
[4] CHU Bicetre, AP HP, Serv Encrinol, F-94270 Le Kremlin Bicetre, France
来源：
DIABETES & METABOLISM | 2008年 / 34卷 / 01期
关键词：
adipocyte; macrophage; obesity; diabetes; visceral adipose tissue; adipokines; metabolic syndrome; review;
D O I：
10.1016/j.diabet.2007.09.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
White adipose tissue was believed to be just an energy-storage organ, but it is now recognized to be an active participant in energy homoeostasis and physiological functions such as immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Adipose tissue is known to express and secrete a variety of products known as 'adipokines', including leptin, adiponectin, resistin and visfatin, as well as cytokines and chemokines such as tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1. The release of adipokines by either adipocytes or adipose tissue-infiltrated macrophages leads to a chronic subinflammatory state that could play a central role in the development of insulin resistance and type 2 diabetes, and the increased risk of cardiovascular disease associated with obesity. (C) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2 / 11
页数：10
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