Inverse Association between High-Density Lipoprotein Cholesterol and Adverse Outcomes among Acute Ischemic Stroke Patients with Diabetes Mellitus

被引:5
|
作者
Hu, Guoliang [1 ,2 ,3 ,4 ]
Pan, Yuesong [2 ]
Wang, Mengxing [2 ]
Meng, Xia [2 ]
Jiang, Yong [2 ]
Li, Zixiao [1 ,2 ,5 ]
Li, Hao [2 ]
Wang, Yongjun [1 ,2 ,3 ,4 ]
Wang, Yilong [1 ,2 ,3 ,4 ,5 ]
机构
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100070, Peoples R China
[2] China Natl Clin Res Ctr Neurol Dis, Beijing 100070, Peoples R China
[3] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100070, Peoples R China
[4] Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100070, Peoples R China
[5] Chinese Inst Brain Res, Beijing 102206, Peoples R China
基金
中国国家自然科学基金;
关键词
high-density lipoprotein cholesterol; lipids; acute ischemic stroke; diabetes mellitus; recurrent stroke; major adverse cardiovascular event; prospective study; HDL CHOLESTEROL; 2019; UPDATE; INHIBITS; MANAGEMENT; RISK; GUIDELINES; INDIVIDUALS; DISEASES; LIPIDS; STEPS;
D O I
10.3390/biomedicines9121947
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A low high-density lipoprotein cholesterol (HDL-C) level is an identified risk factor for cardiovascular diseases. However, results on the association between HDL-C levels and adverse outcomes in diabetic status still remain limited and controversial. Herein, we evaluated the association between HDL-C levels and adverse outcomes among acute ischemic stroke (AIS) patients with diabetes mellitus. The cohort comprised 3824 AIS patients with diabetes mellitus (62.7 +/- 10.5 years; 34.2% women) from the Third China National Stroke Registry (n = 15,166). Patients were classified into five groups by quintiles of HDL-C. The outcomes included recurrent stroke and major adverse cardiovascular events (MACEs) within 1 year. The relationship between HDL-C levels and the risk of adverse outcomes was analyzed by Cox proportional hazards models. Patients in the lowest quintile of HDL-C had a higher risk of recurrent stroke (hazard ratio (HR) 1.59, 95% confidence interval (CI), 1.12-2.25) and MACEs (HR 1.53, 95% CI, 1.09-2.15) during 1-year follow-up compared with those in the highest quintile of HDL-C. There were linear associations between HDL-C levels and the risks of both recurrent stroke and MACEs. Low HDL-C levels were associated with higher risks of recurrent stroke and MACEs within 1 year in AIS patients with diabetes mellitus.
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页数:10
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