Efficacy of voriconazole in treatment of systemic scedosporiosis in neutropenic mice

被引：49

作者：

Capilla, J ^{[1
]}

Serena, C ^{[1
]}

Pastor, FJ ^{[1
]}

Ortoneda, M ^{[1
]}

Guarro, J ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Fac Med, Unitat Microbiol, E-43201 Reus, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 12期

关键词：

D O I：

10.1128/AAC.47.12.3976-3978.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum. The survival of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than that of the control group (P less than or equal to 0.0009). VRC reduced the tissue burden in the spleen and brain (P < 0.001 in both organs) in comparison with that of the control group.

引用

页码：3976 / 3978

页数：3

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