Effects of Fragrance Ingredients on the Uptake of Legionella pneumophila into Acanthamoeba castellanii

被引：1

作者：

Nomura, Harue ^{[1
]}

Takahashi, Sakiko ^{[1
]}

Tohara, Yuki ^{[1
]}

Isshiki, Yasunori ^{[1
]}

Sakuda, Keisuke ^{[2
]}

Sakuma, Katsuya ^{[2
]}

Kondo, Seiichi ^{[1
]}

机构：

[1] Josai Univ, Sch Pharmaceut Sci, Dept Microbiol, 1-1 Keyakidai, Sakado, Saitama 3500295, Japan

[2] Ogawa & Co Ltd, Fragrance R&D Dept, 15-7 Chidori, Chiba 2790032, Japan

来源：

BIOCONTROL SCIENCE | 2018年 / 23卷 / 04期

关键词：

Fragrance ingredients; Antibacterial activity; Amoebicidal activity; Legionella pneumophila; Acanthamoeba castellanii; WATER; SUSCEPTIBILITY; COMPONENTS; OAKMOSS; AMEBAS;

D O I：

10.4265/bio.23.241

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acanthamoeba castellanii, a ubiquitous organism in water environments, is pathogenic toward humans and also is a host for bacteria of the genus Legionella, a causative agent of legionellosis. Fragrance ingredients were investigated for their antibacterial activity against planktonic Legionella pneumophila, amoebicidal activity against A. castellanii, and inhibitory effect against L. pneumophila uptake into A. castellanii. Helional (R) exhibited relatively high antibacterial activity [minimum inhibitory concentration (MIC), 32.0 mu g/mL]. Anis aldehyde, canthoxal, helional (R) and vanillin exhibited amoebicidal activity (IC50 values, 58.4+/-2.0, 71.2+/-14.7, 66.8+/-8.3 and 49.1+/-2.5 mu g/mL, respectively). L. pneumophila pretreatment with sub-MICs (0.25 x MIC) of anis aldehyde, canthoxal, cortex aldehyde 50 percent or vanillin evidently reduced L. pneumophila uptake into A. castellanii (p < 0.01). Thus, fragrance ingredients were good candidates for disinfectant against L. pneumophila and A. castellanii.

引用

页码：241 / 244

页数：4

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